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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Epstein-Barr virus microRNAs in the pathogenesis of human cancers

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Author(s):
Caetano, Brunno Felipe R. [1, 2] ; Jorge, Beatrice Adrianne S. [2, 3] ; Mueller-Coan, Barbara Grasiele [1, 2] ; de Oliveira, Deilson Elgui [1, 2]
Total Authors: 4
Affiliation:
[1] Sao Paulo State Univ, UNESP, Med Sch Botucatu, Av Prof Mario Rubens Guimaraes Montenegro S-N, BR-18618687 Botucatu, SP - Brazil
[2] Sao Paulo State Univ, UNESP, Inst Biotechnol IBTEC, Alameda Tecomarias S-N, BR-18607440 Botucatu, SP - Brazil
[3] Sao Paulo State Univ, UNESP, Inst Biosci Botucatu, R Prof Dr Antonio Celso Wagner Zanin 250, BR-18618689 Botucatu, SP - Brazil
Total Affiliations: 3
Document type: Review article
Source: Cancer Letters; v. 499, p. 14-23, FEB 28 2021.
Web of Science Citations: 1
Abstract

The Epstein-Barr Virus (EBV) is a gamma-herpesvirus involved with a variety of human cancers, notably the endemic Burkitt lymphoma and nasopharyngeal carcinoma. In 2004, EBV was described as one the first known human oncoviruses to encode viral microRNAs (miRNAs), and these molecules were found to interact with viral and host targets. EBV miRNAs modulate biological processes that are critical for carcinogenesis, contributing to cell transformation and tumor progression of EBV-associated cancers. Herein we review and discuss EBV miRNAs as modulators of viral biology and carcinogenesis, as well as their usefulness as putative markers to monitor the onset, progression, and recurrence of cancers associated with the EBV infection. (AU)

FAPESP's process: 19/05061-4 - Effects of Epstein-Barr virus RPMS1 protein expression on lymphoid human cells cultured in vitro
Grantee:Beatrice Adrianne Silva Jorge
Support Opportunities: Scholarships abroad - Research Internship - Master's degree
FAPESP's process: 17/20352-0 - Assessment of Epstein-Barr virus miR-BARTs effects on in vitro properties of human-derived lymphomas and the expression of cell signaling pathways involved in lymphomagenesis
Grantee:Brunno Felipe Ramos Caetano
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/22312-5 - Effects of human endogenous microRNAs on the repertoire of cancer stem cells and Cancer progression using Zebrafish as in vivo model
Grantee:Barbara Grasiele Muller Coan
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 19/03804-0 - Identification of Epstein-Barr Virus (EBV) lytic products involved in B cell-mediated immune evasion
Grantee:Brunno Felipe Ramos Caetano
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 18/12164-1 - Effects of Epstein-Barr protein RPMS1 expression in human cells cultured in vitro
Grantee:Beatrice Adrianne Silva Jorge
Support Opportunities: Scholarships in Brazil - Master