Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Conjugation of superparamagnetic iron oxide nanoparticles and curcumin photosensitizer to assist in photodynamic therapy

Full text
de Santana, Willian Max O. S. [1] ; Caetano, Bruno L. [2, 3, 4] ; de Annunzio, Sarah Raquel [2] ; Pulcinelli, Sandra H. [1] ; Menager, Christine [4] ; Fontana, Carla Raquel [2] ; Santilli, V, Celso
Total Authors: 7
[1] V, Sao Paulo State Univ UNESP, Inst Chem, BR-14800900 Araraquara, SP - Brazil
[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14800903 Araraquara, SP - Brazil
[3] Sorbonne Univ, PSL Univ, CNRS, ESPCI Paris, Soft Matter Sci & Engn, F-75005 Paris - France
[4] Sorbonne Univ, CNRS, PHENIX, Physicochim Electrolytes & Nanosyst Interfaciaux, F-75005 Paris - France
Total Affiliations: 4
Document type: Journal article
Web of Science Citations: 0

In this work, we describe the synthesis and characterization of the SPIONP-CUR conjugate between curcumin (CUR) and superparamagnetic iron oxide nanoparticles (SPIONPs), in addition to its application in photo-dynamic therapy (PDT) using a protocol free of organic solvents as a dispersant. The SPIONP-CUR conjugate was characterized by X-ray diffraction, transmission electron microscopy, zeta potential measurements, Fourier transform infrared spectroscopy, thermogravimetry, magnetometry and magnetic hyperthermia assays. The SPIONP-CUR conjugation occurred by bonding between the keto-enol moiety of CUR and the iron atoms present on the surfaces of the SPIONPs. The conjugate showed heating power under an alternating magnetic field (AMF) and photodynamic action when irradiated with blue LED light. In experiments using PDT against Staphylococcus aureus in the planktonic phase, it was demonstrated that with application of blue light at 3.12 J cm(-2), the conjugate (dispersed in water) caused a total reduction of the bacterial load. In the absence of light, the reduction was insignificant, even after 24 h of contact with the bacteria. (AU)

FAPESP's process: 18/23015-7 - Antimicrobial photodynamic therapy by continuous and switched mode irradiation against Enterococcus faecalis and Cutibacterium acnes
Grantee:Carla Raquel Fontana Mendonça
Support Opportunities: Regular Research Grants
FAPESP's process: 18/09088-1 - Assessment of photodynamic therapy against polymicrobial acne biofilms: a preclinical study
Grantee:Sarah Raquel de Annunzio
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/07822-7 - Conjugation of superparamagnetic nanoparticles of iron oxide and curcumin: association of photodynamic therapy and magnetic hyperthermia
Grantee:Willian Max Oliveira de Souza de Santana
Support Opportunities: Scholarships in Brazil - Master