| Full text | |
| Author(s): |
Araldi, Rodrigo Pinheiro
[1, 2, 3]
;
D'Amelio, Fernanda
[1]
;
Vigerelli, Hugo
[1]
;
de Melo, Thatiana Correa
[1]
;
Kerkis, Irina
[1, 3]
Total Authors: 5
|
| Affiliation: | [1] Inst Butantan, Genet Lab, 1500 Vital Brasil St, BR-05503900 Sao Paulo, SP - Brazil
[2] Univ Fed Sao Pauloa UNIFESP, Escola Paulista Med EPM, Programa Posgrad Endocrinol & Metabol, BR-04021001 Sao Paulo, SP - Brazil
[3] Univ Fed Sao Paulo UNIFESP, Escola Paulista Med EPM, Programa Posgrad Biol Estrutural & Func, BR-04021001 Sao Paulo, SP - Brazil
Total Affiliations: 3
|
| Document type: | Review article |
| Source: | CELLS; v. 9, n. 12 DEC 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
The aging population has contributed to the rapid rise in the global incidence of neurodegenerative diseases. Despite the medical advances, there are no effective treatments for these disorders. Therefore, there is an urgent need for new treatments for these diseases. In this sense, cell therapy has been recognized as the best candidate for treating incurable diseases, such as neurodegenerative disorders. However, the therapeutic use of these cells can be limited by several factors. Thus, there has been a rediscovery that extracellular vesicles, including exosomes, can be alternatively explored in the treatment of these diseases, overcoming the limits of cell-based therapy. In this sense, this review aims to revisit all areas from biology, including biogenesis and the content of exosomes, to biotechnology, proposing the minimal information required to isolate, characterize, and study the content of these vesicles for scientific and/or clinical purposes. (AU) | |
| FAPESP's process: | 10/51051-6 - Adult stem cells versus induced pluripotent stem cells |
| Grantee: | Irina Kerkis |
| Support Opportunities: | Research Projects - Thematic Grants |