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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biochemical and histopathological responses in peripubertal male rats exposed to agrochemicals isolated or in combination: A multivariate data analysis study

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Author(s):
Garcia Aranha, Maria Luiza [1] ; Garcia, Mariana Simoes [1] ; de Carvalho Cavalcante, Deborah Navit [1] ; Gomes Silva, Ana Priscila [1] ; Fontes, Mayana Karoline [2] ; Gusso-Choueri, Paloma Kachel [2] ; Choueri, Rodrigo Brasil [3] ; Perobelli, Juliana Elaine [1]
Total Authors: 8
Affiliation:
[1] Univ Fed Sao Paulo UNIFESP, Dept Ciencias Mar, Expt Toxicol Lab, Santos, SP - Brazil
[2] Univ Estadual Paulista UNESP, Nucleo Estudos Poluicao & Ecotoxicol Aquat, Campus Litoral Paulista, Sao Vicente, SP - Brazil
[3] Univ Fed Sao Paulo UNIFESP, Dept Ciencias Mar, Santos, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Toxicology; v. 447, JAN 15 2021.
Web of Science Citations: 0
Abstract

The widespread use of agrochemicals results in the exposure of the general human population, including children, to several of these chemicals simultaneously. In the present preclinical study, it was investigated the hepatic damages caused by exposure to acephate, carbendazim and mancozeb when administered alone or in different combinations (binary and ternary). Juvenile male Wistar rats were exposed to agrochemicals from postnatal day 53, by gavage. The doses of agrochemicals applied here were determined from previous studies whose results showed no signs of systemic toxicity. All exposures provoked a significant increase in DNA damage (except for acephate alone) and activation of the xenobiotic biotransformation system (except for the ternary mixture). Interestingly, the ternary mixture did not exhibit an exacerbation in adverse effects caused by agrochemicals isolated or in binary combination, even though they are sharing genotoxicity damage induction as a common toxicity pathway. Conversely, some effects observed for isolated or binary combinations of agrochemicals were not observed for ternary combination, suggesting a chemical interaction that could imply antagonism character. Using a multivariate data analysis approach, exposure to isolated agrochemicals were related to a group of adverse effects characterized by hepatic lesion and the attempt of the tissue to mobilize defense cells and increase mitotic rates to minimize damages. Binary mixtures also share similarities in relation to the effects they exhibited, mainly a moderate to high increase in the GST activity and in histopathological alterations suggesting that binary combinations trigger an increased response of the mechanism of xenobiotics biotransformation. Together, obtained results bring important insights regarding adverse effects and possible interaction of the three agrochemicals whose residues are commonly detected in agro-food products. (AU)

FAPESP's process: 16/24033-3 - Ecotoxicological study and environmental risk assessment of cocaine in marine ecosystems
Grantee:Mayana Karoline Fontes
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/23063-9 - Reproductive, endocrine, cytotoxic and genotoxic effects of acephate, carbendazim and mancozeb, isolated or in mixture: study of juvenile toxicity in rats
Grantee:Juliana Elaine Perobelli
Support Opportunities: Regular Research Grants
FAPESP's process: 19/04588-9 - Reproductive, endocrine, cytotoxic and genotoxic effects of acephate, carbendazim and mancozeb isolated or in mixture: study of juvenile toxicity in rats
Grantee:Maria Luiza Garcia Aranha
Support Opportunities: Scholarships in Brazil - Technical Training Program - Technical Training
FAPESP's process: 17/04970-5 - Relationship between metal concentrations in the sediment, bioaccumulation and toxic responses in p. vivipara:subsidies for the environmental risk assessment
Grantee:Paloma Kachel Gusso Choueri
Support Opportunities: Scholarships in Brazil - Post-Doctoral