Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Combined Exercise Training and l-Glutamine Supplementation Enhances Both Humoral and Cellular Immune Responses after Influenza Virus Vaccination in Elderly Subjects

Full text
Author(s):
Show less -
Monteiro, Fernanda R. [1, 2] ; Roseira, Tamaris [1, 2] ; Amaral, Jonatas B. [1] ; Paixao, Vitoria [1] ; Almeida, Ewin B. [1] ; Foster, Roberta [1, 2] ; Sperandio, Adriane [2] ; Rossi, Marcelo [1] ; Amirato, Gislene R. [1] ; Apostolico, Juliana S. [3] ; Santos, Carlos A. F. [1] ; Felismino, Eduardo S. [4] ; Leal, Fabyano B. [5] ; Thomazelli, Luciano M. [5] ; Durigon, Edison L. [5, 6] ; Oliveira, Danielle B. L. [7, 5] ; Vieira, Rodolfo P. [8, 9, 10] ; Santos, Juliana M. B. [10] ; Bachi, Andre L. L. [8, 4, 1]
Total Authors: 19
Affiliation:
[1] Fed Univ Sao Paulo UNIFESP, Dept Otorhinolaryngol, ENT Lab, BR-04025002 Sao Paulo - Brazil
[2] Method Fac Sao Paulo FAMESP, BR-04046200 Sao Paulo - Brazil
[3] Fed Univ Paulo UNIFESP EPM, Dept Microbiol Immunol & Parasitol, BR-04025002 Sao Paulo - Brazil
[4] Santo Amaro Univ UNISA, Postgrad Program Hlth Sci, BR-04829300 Sao Paulo - Brazil
[5] Univ Sao Paulo, Inst Biomed Sci, BR-05508900 Sao Paulo - Brazil
[6] Sci Platform Pasteur USP, BR-05508020 Sao Paulo - Brazil
[7] Hosp Israelita Albert Einstein, BR-05652900 Sao Paulo - Brazil
[8] Brazilian Inst Teaching & Res Pulm & Exercise Imm, BR-12245520 Sao Jose Dos Campos - Brazil
[9] Univ Brasil, Postgrad Program Bioengn & Biomed Engn, BR-08230030 Sao Paulo - Brazil
[10] Fed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human & Rehabil, BR-11060001 Santos, SP - Brazil
Total Affiliations: 10
Document type: Journal article
Source: VACCINES; v. 8, n. 4 DEC 2020.
Web of Science Citations: 1
Abstract

Background: Since aging affects the immune responses against vaccination, the present study evaluated the effects of L-glutamine (Gln) supplementation in the humoral and cellular immune responses in elderly subjects, practitioners or not, of physical exercise training. Methods: Eighty-four elderly people (aged 72.6 +/- 6.1), non-practitioners (NP, n = 31), and practitioners of combined-exercise training (CET, n = 53) were submitted to Influenza virus vaccination and supplemented with Gln (0.3 g/kg of weight + 10 g of maltodextrin, groups: NP-Gln (n = 14), and CET-Gln (n = 26)), or placebo (10 g of maltodextrin, groups: NP-PL (n = 17), and CET-PL (n = 27)). Blood samples were collected pre (baseline) and 30 days post-vaccination and supplementation. Results: Comparing with the baseline values, whereas the NP-Gln and CET-PL groups showed higher specific-IgM levels, the CET-Gln group showed higher specific-IgM and IgA levels post-vaccination. The titer rate of hemagglutination inhibition was higher in the CET-Gln, NP-PL, and NP-Gln groups post-vaccination than baseline values. The absolute number of naive and effector CD4+ T cells was higher especially in the NP-Gln and CET-Gln groups, whilst activated CD4+ T cells were higher in CET subgroups post-vaccination. Conclusion: Our results showed that both l-glutamine supplementation and combined-exercise training can improve the immune responses to the Influenza virus vaccine in elderly subjects. (AU)

FAPESP's process: 19/13188-4 - Study of the effects of glutamine supplementation on the immunophenotyping and activation profile of t and b lymphocytes from practicing or NON-EXERCISING seniors submitted to influenza virus vaccination
Grantee:Tamaris Roseira dos Reis Pavao
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 19/13094-0 - Evaluation of the influence of combined physical exercise and L-glutamine supplementation on the inflammatory profile and response of specific antibodies to the vaccine against the influenza virus in elderly people
Grantee:Fernanda Rodrigues Monteiro
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals
Grantee:Rodolfo de Paula Vieira
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 19/14115-0 - Influence of L-glutamine supplementation in the sarcopenia and immune/inflammatory response both systemic and in the respiratory tract of elderly practitioners or not of a regular program of combined physical exercises submitted to Influenza virus vaccine
Grantee:André Luis Lacerda Bachi
Support Opportunities: Regular Research Grants