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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Combined Exercise Training and l-Glutamine Supplementation Enhances Both Humoral and Cellular Immune Responses after Influenza Virus Vaccination in Elderly Subjects

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Monteiro, Fernanda R. [1, 2] ; Roseira, Tamaris [1, 2] ; Amaral, Jonatas B. [1] ; Paixao, Vitoria [1] ; Almeida, Ewin B. [1] ; Foster, Roberta [1, 2] ; Sperandio, Adriane [2] ; Rossi, Marcelo [1] ; Amirato, Gislene R. [1] ; Apostolico, Juliana S. [3] ; Santos, Carlos A. F. [1] ; Felismino, Eduardo S. [4] ; Leal, Fabyano B. [5] ; Thomazelli, Luciano M. [5] ; Durigon, Edison L. [5, 6] ; Oliveira, Danielle B. L. [7, 5] ; Vieira, Rodolfo P. [8, 9, 10] ; Santos, Juliana M. B. [10] ; Bachi, Andre L. L. [8, 4, 1]
Total Authors: 19
[1] Fed Univ Sao Paulo UNIFESP, Dept Otorhinolaryngol, ENT Lab, BR-04025002 Sao Paulo - Brazil
[2] Method Fac Sao Paulo FAMESP, BR-04046200 Sao Paulo - Brazil
[3] Fed Univ Paulo UNIFESP EPM, Dept Microbiol Immunol & Parasitol, BR-04025002 Sao Paulo - Brazil
[4] Santo Amaro Univ UNISA, Postgrad Program Hlth Sci, BR-04829300 Sao Paulo - Brazil
[5] Univ Sao Paulo, Inst Biomed Sci, BR-05508900 Sao Paulo - Brazil
[6] Sci Platform Pasteur USP, BR-05508020 Sao Paulo - Brazil
[7] Hosp Israelita Albert Einstein, BR-05652900 Sao Paulo - Brazil
[8] Brazilian Inst Teaching & Res Pulm & Exercise Imm, BR-12245520 Sao Jose Dos Campos - Brazil
[9] Univ Brasil, Postgrad Program Bioengn & Biomed Engn, BR-08230030 Sao Paulo - Brazil
[10] Fed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human & Rehabil, BR-11060001 Santos, SP - Brazil
Total Affiliations: 10
Document type: Journal article
Source: VACCINES; v. 8, n. 4 DEC 2020.
Web of Science Citations: 1

Background: Since aging affects the immune responses against vaccination, the present study evaluated the effects of L-glutamine (Gln) supplementation in the humoral and cellular immune responses in elderly subjects, practitioners or not, of physical exercise training. Methods: Eighty-four elderly people (aged 72.6 +/- 6.1), non-practitioners (NP, n = 31), and practitioners of combined-exercise training (CET, n = 53) were submitted to Influenza virus vaccination and supplemented with Gln (0.3 g/kg of weight + 10 g of maltodextrin, groups: NP-Gln (n = 14), and CET-Gln (n = 26)), or placebo (10 g of maltodextrin, groups: NP-PL (n = 17), and CET-PL (n = 27)). Blood samples were collected pre (baseline) and 30 days post-vaccination and supplementation. Results: Comparing with the baseline values, whereas the NP-Gln and CET-PL groups showed higher specific-IgM levels, the CET-Gln group showed higher specific-IgM and IgA levels post-vaccination. The titer rate of hemagglutination inhibition was higher in the CET-Gln, NP-PL, and NP-Gln groups post-vaccination than baseline values. The absolute number of naive and effector CD4+ T cells was higher especially in the NP-Gln and CET-Gln groups, whilst activated CD4+ T cells were higher in CET subgroups post-vaccination. Conclusion: Our results showed that both l-glutamine supplementation and combined-exercise training can improve the immune responses to the Influenza virus vaccine in elderly subjects. (AU)

FAPESP's process: 19/13188-4 - Study of the effects of glutamine supplementation on the immunophenotyping and activation profile of t and b lymphocytes from practicing or NON-EXERCISING seniors submitted to influenza virus vaccination
Grantee:Tamaris Roseira dos Reis Pavao
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 19/13094-0 - Evaluation of the influence of combined physical exercise and L-glutamine supplementation on the inflammatory profile and response of specific antibodies to the vaccine against the influenza virus in elderly people
Grantee:Fernanda Rodrigues Monteiro
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals
Grantee:Rodolfo de Paula Vieira
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 19/14115-0 - Influence of L-glutamine supplementation in the sarcopenia and immune/inflammatory response both systemic and in the respiratory tract of elderly practitioners or not of a regular program of combined physical exercises submitted to Influenza virus vaccine
Grantee:André Luis Lacerda Bachi
Support Opportunities: Regular Research Grants