| Full text | |
| Author(s): Show less - |
Monteiro, Fernanda R.
[1, 2]
;
Roseira, Tamaris
[1, 2]
;
Amaral, Jonatas B.
[1]
;
Paixao, Vitoria
[1]
;
Almeida, Ewin B.
[1]
;
Foster, Roberta
[1, 2]
;
Sperandio, Adriane
[2]
;
Rossi, Marcelo
[1]
;
Amirato, Gislene R.
[1]
;
Apostolico, Juliana S.
[3]
;
Santos, Carlos A. F.
[1]
;
Felismino, Eduardo S.
[4]
;
Leal, Fabyano B.
[5]
;
Thomazelli, Luciano M.
[5]
;
Durigon, Edison L.
[5, 6]
;
Oliveira, Danielle B. L.
[7, 5]
;
Vieira, Rodolfo P.
[8, 9, 10]
;
Santos, Juliana M. B.
[10]
;
Bachi, Andre L. L.
[8, 4, 1]
Total Authors: 19
|
| Affiliation: | [1] Fed Univ Sao Paulo UNIFESP, Dept Otorhinolaryngol, ENT Lab, BR-04025002 Sao Paulo - Brazil
[2] Method Fac Sao Paulo FAMESP, BR-04046200 Sao Paulo - Brazil
[3] Fed Univ Paulo UNIFESP EPM, Dept Microbiol Immunol & Parasitol, BR-04025002 Sao Paulo - Brazil
[4] Santo Amaro Univ UNISA, Postgrad Program Hlth Sci, BR-04829300 Sao Paulo - Brazil
[5] Univ Sao Paulo, Inst Biomed Sci, BR-05508900 Sao Paulo - Brazil
[6] Sci Platform Pasteur USP, BR-05508020 Sao Paulo - Brazil
[7] Hosp Israelita Albert Einstein, BR-05652900 Sao Paulo - Brazil
[8] Brazilian Inst Teaching & Res Pulm & Exercise Imm, BR-12245520 Sao Jose Dos Campos - Brazil
[9] Univ Brasil, Postgrad Program Bioengn & Biomed Engn, BR-08230030 Sao Paulo - Brazil
[10] Fed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human & Rehabil, BR-11060001 Santos, SP - Brazil
Total Affiliations: 10
|
| Document type: | Journal article |
| Source: | VACCINES; v. 8, n. 4 DEC 2020. |
| Web of Science Citations: | 1 |
| Abstract | |
Background: Since aging affects the immune responses against vaccination, the present study evaluated the effects of L-glutamine (Gln) supplementation in the humoral and cellular immune responses in elderly subjects, practitioners or not, of physical exercise training. Methods: Eighty-four elderly people (aged 72.6 +/- 6.1), non-practitioners (NP, n = 31), and practitioners of combined-exercise training (CET, n = 53) were submitted to Influenza virus vaccination and supplemented with Gln (0.3 g/kg of weight + 10 g of maltodextrin, groups: NP-Gln (n = 14), and CET-Gln (n = 26)), or placebo (10 g of maltodextrin, groups: NP-PL (n = 17), and CET-PL (n = 27)). Blood samples were collected pre (baseline) and 30 days post-vaccination and supplementation. Results: Comparing with the baseline values, whereas the NP-Gln and CET-PL groups showed higher specific-IgM levels, the CET-Gln group showed higher specific-IgM and IgA levels post-vaccination. The titer rate of hemagglutination inhibition was higher in the CET-Gln, NP-PL, and NP-Gln groups post-vaccination than baseline values. The absolute number of naive and effector CD4+ T cells was higher especially in the NP-Gln and CET-Gln groups, whilst activated CD4+ T cells were higher in CET subgroups post-vaccination. Conclusion: Our results showed that both l-glutamine supplementation and combined-exercise training can improve the immune responses to the Influenza virus vaccine in elderly subjects. (AU) | |
| FAPESP's process: | 19/13188-4 - Study of the effects of glutamine supplementation on the immunophenotyping and activation profile of t and b lymphocytes from practicing or NON-EXERCISING seniors submitted to influenza virus vaccination |
| Grantee: | Tamaris Roseira dos Reis Pavao |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 19/13094-0 - Evaluation of the influence of combined physical exercise and L-glutamine supplementation on the inflammatory profile and response of specific antibodies to the vaccine against the influenza virus in elderly people |
| Grantee: | Fernanda Rodrigues Monteiro |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals |
| Grantee: | Rodolfo de Paula Vieira |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 19/14115-0 - Influence of L-glutamine supplementation in the sarcopenia and immune/inflammatory response both systemic and in the respiratory tract of elderly practitioners or not of a regular program of combined physical exercises submitted to Influenza virus vaccine |
| Grantee: | André Luis Lacerda Bachi |
| Support Opportunities: | Regular Research Grants |