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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Curcumin as a photosensitizer: From molecular structure to recent advances in antimicrobial photodynamic therapy

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Dias, Lucas D. [1] ; Blanco, Kate C. [1] ; Mfouo-Tynga, Ivan S. [1] ; Inada, Natalia M. [1] ; Bagnato, Vanderlei S. [1, 2]
Total Authors: 5
[1] Univ Sao Paulo, Sao Carlos Inst Phys, BR-13566590 Sao Carlos, SP - Brazil
[2] Texas A&M Univ, Dept Biomed Engn, College Stn, TX 77843 - USA
Total Affiliations: 2
Document type: Review article
Web of Science Citations: 0

Nowadays multi-drug resistant microorganisms is a serious public health problem worldwide. To overcome it, new antimicrobial strategies have been developed. Among them, antimicrobial photodynamic therapy is an efficient tool against various micro-organisms in different medical and healthcare fields. The antimicrobial photodynamic protocol is based on the interaction of a photosensitizer, molecular oxygen, and an appropriate light source. Herein, we described the main physical and chemical proprieties of curcumin, an useful natural photosensitizer, including its degradation pathways, analytical methods for quantification, extraction method, synthetic methodologies, and pharmaceutical formulations used. Moreover, a comprehensive review of the past 10 years (2010-2019) concerning the application of curcumin as photosensitizer against microorganisms is described and discussed. (C) 2020 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 19/14885-0 - Evaluation of cell death mechanisms induced by photodynamic therapy using different photosensitizers
Grantee:Ivan Sosthene Mfouo Tynga
Support Opportunities: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
Grantee:Vanderlei Salvador Bagnato
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 14/50857-8 - National Institute in Basic Optics and Applied to Life Sciences
Grantee:Vanderlei Salvador Bagnato
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 19/12694-3 - Treatment of pharyngotonsillitis with photodynamic action
Grantee:Kate Cristina Blanco
Support Opportunities: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 19/13569-8 - Study of the Mechanisms of Action in Photodynamic Therapy: From Photosensitizer to Practical Application
Grantee:Lucas Danilo Dias
Support Opportunities: Scholarships in Brazil - Post-Doctorate