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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Engineering printable composites of poly (epsilon-polycaprolactone) / beta-tricalcium phosphate for biomedical applications

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Goncalves Beatrice, Cesar Augusto [1] ; Boriolo Shimomura, Kawany Munique [2] ; Backes, Eduardo Henrique [1] ; Harb, Samarah Vargas [2] ; Costa, Lidiane Cristina [1, 2] ; Passador, Fabio Roberto [3] ; Pessan, Luiz Antonio [1, 2]
Total Authors: 7
[1] Univ Fed Sao Carlos, Grad Program Mat Sci & Engn, Rodovia Washington Luiz, Km 235, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Dept Mat Engn, Rodovia Washington Luiz, Km 235, BR-13565905 Sao Carlos, SP - Brazil
[3] Univ Fed Sao Paulo, Inst Sci & Technol, Rua Talim 330, BR-12231280 Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Polymer Composites; v. 42, n. 3 DEC 2020.
Web of Science Citations: 0

The incorporation of bioactive beta-tricalcium phosphate (TCP) into poly (epsilon-polycaprolactone) (PCL) originates a composite biomaterial with required properties for a variety of biomedical application. We manufactured bioactive composites of PCL/TCP by melt compounding and assessed their rheological, structural, and thermal behavior, envisioning the use of the composites as filaments for additive manufacturing via fused filament fabrication (FFF). Biocomposites of PCL with 5 wt% and 10 wt% of TCP presented similar thermal stability, crystallinity, molecular weight, and rheological behavior of neat PCL, while the addition of 25 wt% TCP leads to the formation of TCP agglomerates and increased viscosity. These results show that low concentrations of TCP in the PCL matrix make it more suitable for FFF since no change in the printing process is required. PCL/TCP filaments were fabricated by a twin-screw extruder and used to print scaffolds using FFF. The possibility to design scaffolds with specific size, geometry, and porosity enables the application of diverse types of tissue engineering. Herein, we demonstrated the feasibility of the fabrication of 3D printed PCL/TCP scaffolds for bone regeneration with improved mechanical properties and controlled geometry. (AU)

FAPESP's process: 17/11366-7 - Development of bio-inspired PLA/bioglass scaffolds via 3D printed
Grantee:Eduardo Henrique Backes
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 18/26060-3 - Bioactive and bactericidal scaffolds for bone regeneration via 3D printing
Grantee:Samarah Vargas Harb
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/09609-9 - Development of bioinspired scaffolds of PLA/bioactive ceramic fillers through 3D printing
Grantee:Luiz Antonio Pessan
Support type: Regular Research Grants
FAPESP's process: 18/14151-4 - Development and characterization of bioactive PCL/TCP composites
Grantee:Kawany Munique Boriolo Shimomura
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 11/21313-1 - Study of the reaction kinetic and the addition of the metal deactivators in the grafting of maleic anhydride onto polypropylene in the presence and absence of the nanoparticles
Grantee:Silvia Helena Prado Bettini
Support type: Regular Research Grants