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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Identification of potential molecular pathways involved in prostate carcinogenesis in offspring exposed to maternal malnutrition

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Alcantara Santos, Sergio Alexandre [1] ; Lima Camargo, Ana Carolina [1] ; Constantino, Flavia Bessi [1] ; Colombelli, Ketlin Thassiani [1] ; Frediani Portela, Luiz Marcos [1] ; Fioretto, Matheus Naia [1] ; Souza Vieira, Jose Cavalcante [2] ; Padilha, Pedro Magalhaes [2] ; de Oliveira, Mateus Betta [1] ; Felisbino, Sergio Luis [1] ; Carvalho, Robson Francisco [1] ; Justulin, Luis Antonio [1]
Total Authors: 12
[1] Sao Paulo State Univ UNESP, Inst Biosci, Dept Struct & Funct Biol, BR-18618689 Botucatu, SP - Brazil
[2] Sao Paulo State Univ Unesp, Inst Biosci, Dept Chem & Biol Sci, BR-18618689 Botucatu, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: AGING-US; v. 12, n. 20, p. 19954-19978, OCT 31 2020.
Web of Science Citations: 0

The developmental origins of health and disease concept links adult diseases with early-life exposure to inappropriate environmental conditions. Intrauterine and postnatal malnutrition may lead to an increased incidence of type 2 diabetes, obesity, and cardiovascular diseases. Maternal malnutrition (MM) has also been associated with prostate carcinogenesis. However, the molecular mechanisms associated with this condition remain poorly understood. Using a proteomic analysis, we demonstrated that MM changed the levels of proteins associated with growth factors, estrogen signaling, detoxification, and energy metabolism in the prostate of both young and old rats. These animals also showed increased levels of molecular markers of endoplasmic reticulum function and histones. We further performed an in silico analysis that identified commonly deregulated proteins in the ventral prostate of old rats submitted to MM with a mouse model and patients with prostate cancer. In conclusion, our results demonstrated that estrogenic signaling pathways, endoplasmic reticulum functions, energy metabolism, and molecular sensors of protein folding and Ca2+ homeostasis, besides histone, and RAS-GTPase family appear to be involved in this process. Knowledge of these factors may raise discussions regarding the role of maternal dietary intervention as a public policy for the lifelong prevention of chronic diseases. (AU)

FAPESP's process: 17/08715-0 - Integrative analysis of the transcriptome and proteomics of the ventral prostate of rat offspring submitted to maternal protein restriction
Grantee:Ana Carolina Lima Camargo
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/01063-7 - Integrative global analyzes of the rat ventral prostate submitted to maternal protein restriction and its repercussions with aging
Grantee:Luis Antonio Justulin Junior
Support Opportunities: Regular Research Grants
FAPESP's process: 14/08531-8 - Impact of protein restriction during pregnancy and lactation on rat prostate: relation between the signaling pathway of Insulin/IGF, development and aging
Grantee:Sérgio Alexandre Alcantara dos Santos
Support Opportunities: Scholarships in Brazil - Doctorate