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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Benzoic Acid Combined with Essential Oils Can Be an Alternative to the Use of Antibiotic Growth Promoters for Piglets Challenged with E. coli F4

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Author(s):
Rodrigues, Leticia Mendonca [1] ; Neto, Tulio Otavio de Araujo Lima [1] ; Garbossa, Cesar Augusto Pospissil [2] ; Martins, Claudia Cassimira da Silva [3] ; Garcez, Dino [3] ; Alves, Laya Kannan Silva [2] ; de Abreu, Marvio Lobao Teixeira [1] ; Ferreira, Rony Antonio [1] ; Cantarelli, Vinicius de Souza [1]
Total Authors: 9
Affiliation:
[1] Univ Fed Lavras, Dept Anim Sci, BR-37200000 Lavras - Brazil
[2] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Anim Nutr & Prod, BR-13635900 Pirassununga - Brazil
[3] DSM Nutr Prod, BR-01452001 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: ANIMALS; v. 10, n. 11 NOV 2020.
Web of Science Citations: 0
Abstract

Simple Summary The use of antibiotics as growth promoters for swine must be minimized as it can promote resistance in microorganisms. Therefore, it is essential to search for alternative additives. This study aimed to investigate the effects of benzoic acid and a blend of essential oils (thymol, 2-methoxyphenol, eugenol, piperine, and curcumin) on the performance and intestinal health of weanling piglets challenged with Escherichia coli F4. The combination of benzoic acid and essential oils at 3 g/kg improved the piglets' average daily gain and consequently their final body weight and it is an economically viable alternative to replace colistin. These results could have a great impact on society, contributing to the one heath concept and demonstrating the ability to replace antibiotics as growth promoters and thus minimize the chance of causing bacteria resistance. Benzoic acid (BA) and essential oils (EOs) (thymol, 2-methoxyphenol, eugenol, piperine, and curcumin) are being studied to minimize the impairment of gastrointestinal functions in weanling piglets. This study evaluates the effects of combining BA and EO on the performance and intestinal health of piglets challenged with E. coli F4 (1 mL, 10(6) CFU/mL). In total, 270 weaned piglets were used in a randomized block design with six treatments: positive control, with 40 mg/kg colistin (PC); negative control, without the growth promoter (NC); negative control +5 g/kg benzoic acid (BA); negative control +2 g/kg combination of BA+EO (BA+EO2); negative control +3 g/kg combination of BA+EO (BA+EO3); negative control +4 g/kg combination of BA+EO (BA+EO4). BA+EO3 presented a greater average daily gain (ADG) (p = 0.0013) and better feed-to-gain ratio (p = 0.0138), compared to NC, from 21 to 35 days age. For the total period, BA, BA+EO3, and BA+EO4 were similar to PC and superior to NC for ADG (p = 0.0002) and final body weight (BW) (p = 0.0002). No difference (p > 0.05) was verified for diarrhea, microbial population, production of volatile fatty acids, pH, weight of organs, cellular proliferation, and cholecystokinin count. NC and BA+EO4 resulted in a higher villus height in the jejunum (p = 0.0120) compared to BA+EO3. The use of BA or the combination of BA and EO at 3 g/kg provides improved performance, aside from being an economically viable alternative to replace colistin. (AU)

FAPESP's process: 19/17453-4 - Development of the swine production cost calculation model and production cost indicator
Grantee:Laya Kannan Silva Alves
Support type: Scholarships in Brazil - Master