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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Perspective: The Potential Effects of Naringenin in COVID-19

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Alberca, Ricardo Wesley [1, 2] ; Teixeira, Franciane Mouradian Emidio [3] ; Beserra, Danielle Rosa [1, 2] ; de Oliveira, Emily Araujo [1, 2] ; Andrade, Milena Mary de Souza [1, 2] ; Pietrobon, Anna Julia [3] ; Sato, Maria Notomi [1, 2]
Total Authors: 7
[1] Univ Sao Paulo, Inst Trop Med Sao Paulo, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Dept Dermatol, Lab Dermatol & Immunodeficiencies, LIM 56, Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Biomed Sci, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: FRONTIERS IN IMMUNOLOGY; v. 11, SEP 25 2020.
Web of Science Citations: 0

Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), was declared a pandemic by the World Health Organization in March 2020. Severe COVID-19 cases develop severe acute respiratory syndrome, which can result in multiple organ failure, sepsis, and death. The higher risk group includes the elderly and subjects with pre-existing chronic illnesses such as obesity, hypertension, and diabetes. To date, no specific treatment or vaccine is available for COVID-19. Among many compounds, naringenin (NAR) a flavonoid present in citrus fruits has been investigated for antiviral and anti-inflammatory properties like reducing viral replication and cytokine production. In this perspective, we summarize NAR potential anti-inflammatory role in COVID-19 associated risk factors and SARS-CoV-2 infection. (AU)

FAPESP's process: 19/02679-7 - Effect of maternal and paternal supplementation with antioxidant in pulmonary inflammatory process of the offspring of mice
Grantee:Ricardo Wesley Alberca Custódio
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 17/18199-9 - Effect of maternal supplementation with retinoic acid during breastfeeding on the immune response of mice offspring
Grantee:Maria Notomi Sato
Support Opportunities: Regular Research Grants
FAPESP's process: 18/18230-6 - Evaluation of the efficacy of the Zika Virus chimeric DNA vaccine and the lysosomal-associated membrane protein in mice
Grantee:Franciane Mouradian Emidio Teixeira
Support Opportunities: Scholarships in Brazil - Doctorate