Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Epigenetic Mechanisms in Canine Cancer

Full text
Xavier, Pedro Luiz Porfirio [1] ; Mueller, Susanne [2, 3] ; Fukumasu, Heidge [1]
Total Authors: 3
[1] Univ Sao Paulo, Fac Anim Sci & Food Engn, Dept Vet Med, Lab Comparat & Translat Oncol LOCT, Pirassununga - Brazil
[2] Goethe Univ Frankfurt, Struct Genom Consortium, Buchmann Inst Mol Life Sci, Frankfurt - Germany
[3] Goethe Univ Frankfurt, Inst Pharmaceut Chem, Buchmann Inst Mol Life Sci, Frankfurt - Germany
Total Affiliations: 3
Document type: Review article
Source: FRONTIERS IN ONCOLOGY; v. 10, OCT 23 2020.
Web of Science Citations: 0

A plethora of data has highlighted the role of epigenetics in the development of cancer. Initiation and progression of different cancer types are associated with a variety of changes of epigenetic mechanisms, including aberrant DNA methylation, histone modifications, and miRNA expression. At the same time, advances in the available epigenetic tools allow to investigate and reverse these epigenetic changes and form the basis for the development of anticancer drugs in human oncology. Although human and canine cancer shares several common features, only recently that studies emerged investigating the epigenetic landscape in canine cancer and applying epigenetic modulators to canine cancer. This review focuses on the existing studies involving epigenetic changes in different types of canine cancer and the use of small-molecule inhibitors in canine cancer cells. (AU)

FAPESP's process: 19/05778-6 - Combined inhibition of BET proteins AND HDACs as an effective strategy for the treatment of mammary cancer: a comparative study
Grantee:Pedro Luiz Porfirio Xavier
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 17/11966-4 - Epigenetic modulations and self-renewal potential of canine mammary cancer cells: the search for potential therapeutic targets
Grantee:Pedro Luiz Porfirio Xavier
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/02493-7 - Mammary tumors of dogs and the cancer stem cell theory: a comparative and translational approach
Grantee:Heidge Fukumasu
Support type: Research Grants - Young Investigators Grants