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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

I mmunosenescence and Inflammaging: Risk Factors of Severe COVID-19 in Older People

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Pietrobon, Anna Julia [1, 2] ; Teixeira, Franciane Mouradian Emidio [1, 2] ; Sato, Maria Notomi [2]
Total Authors: 3
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Trop Med Inst Sao Paulo, LIM 56, Lab Dermatol & Immunodeficiencies, , Dept Dermatol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: FRONTIERS IN IMMUNOLOGY; v. 11, OCT 27 2020.
Web of Science Citations: 3

Old individuals are more susceptible to various infections due to immunological changes that occur during the aging process. These changes named collectively as ``immunosenescence{''} include decreases in both the innate and adaptive immune responses in addition to the exacerbated production of inflammatory cytokines. This scenario of immunological dysfunction and its relationship with disease development in older people has been widely studied, especially in infections that can be fatal, such as influenza and, more recently, COVID-19. In the current scenario of SARS-CoV-2 infection, many mechanisms of disease pathogenesis in old individuals have been proposed. To better understand the dynamics of COVID-19 in this group, aspects related to immunological senescence must be well elucidated. In this article, we discuss the main mechanisms involved in immunosenescence and their possible correlations with the susceptibility of individuals of advanced age to SARS-CoV-2 infection and the more severe conditions of the disease. (AU)

FAPESP's process: 17/18199-9 - Effect of maternal supplementation with retinoic acid during breastfeeding on the immune response of mice offspring
Grantee:Maria Notomi Sato
Support Opportunities: Regular Research Grants
FAPESP's process: 18/18230-6 - Evaluation of the efficacy of the Zika Virus chimeric DNA vaccine and the lysosomal-associated membrane protein in mice
Grantee:Franciane Mouradian Emidio Teixeira
Support Opportunities: Scholarships in Brazil - Doctorate