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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evaluation of different solvents and solubility parameters on the morphology and diameter of electrospun pullulan nanofibers for curcumin entrapment

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Guerrini, Lilia M. [1] ; Oliveira, Mauricio P. [1, 2] ; Stapait, Camila C. [3] ; Maric, Milan [2] ; Santos, Amilton M. [4] ; Demarquette, Nicole R. [3]
Total Authors: 6
[1] Univ Fed Sao Paulo, Dept Sci & Technol, Inst Sci & Technol, Sao Jose Dos Campos - Brazil
[2] McGill Univ, Dept Chem Engn, Montreal, PQ - Canada
[3] Ecole Technol Super ETS, Dept Mech Engn, Montreal, PQ - Canada
[4] Univ Sao Paulo, Dept Chem Engn, Sch Engn Lorena, Lorena - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Carbohydrate Polymers; v. 251, JAN 1 2021.
Web of Science Citations: 0

In this work, the effect of different solvents and solvent binary mixtures on the morphology of electrospun pullulan (Pull) nanofibers was evaluated. The solution viscosities, interactions between solvent and polymer, as well as, solvent vapor pressure, were correlated to the morphology and diameters of the nanofibers. Water, dimethylformamide (DMF) and dimethyl sulfoxide (DMSO) and Teas graphs that rely on the use of Hildebrand solubility parameters were used to identify the most suitable mixtures of solvents. The best binary mixture of solvents to produce Pull nanofibers without defects and with small diameters (203 +/- 32 nm) was DMF/DMSO in the ratio of 70/30 wt.%. Pull nanofibers containing 3 and 5 wt. % of curcumin (Curt) in a mixture of DMF/DMSO (70/30 wt.%) were then obtained, and the entrapment efficiency was evaluated using H-1 NMR and a UV-vis spectrophotometer. The results obtained in this work create a new approach for the production of Pull nanofibers for drug delivery systems. (AU)

FAPESP's process: 19/04952-2 - Production of pullulan graft copolymers nanomats by scale up electrospinning aiming applications as drug delivery system
Grantee:Lilia Müller Guerrini
Support Opportunities: Scholarships abroad - Research
FAPESP's process: 19/05282-0 - Synthesis of amphiphilic graf copolymers by combination of synthetic and bio-derived polymers for obtaining nanoparticles and nanofibers for biomedical and industrial applications
Grantee:Maurício Pinheiro de Oliveira
Support Opportunities: Scholarships abroad - Research