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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Synergistic Supramolecular Effect on the Electro-Oxidation of Biological Relevant Molecules: A Novel Sensor for Simultaneous Determination of Epinephrine and Uric Acid in Human Urine Using MWCNT and a Copper(II) Complex

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Bruno R. L. Ferraz ; Fernando R. F. Leite [2] ; Eliziana S. Gomes [3] ; Marcus L. Sousa [4] ; Eduardo G. R. de Arruda [5] ; Juliano A. Bonacin [6] ; Andréa R. Malagutti [7] ; André L. B. Formiga [8]
Total Authors: 8
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 31, n. 11, p. 2396-2408, 2020-10-30.

In this paper a novel supramolecular strategy to improve the efficiency of a voltammetric sensor to determine two biologically relevant molecules (epinephrine (EP) and uric acid (UA)) is presented. The strategy is based on the use of a glassy carbon electrode modified with a copper(II) complex ([Cu(H2dimpy)Cl]PF6) adsorbed on multi-walled carbon nanotubes (MWCNTs). The [Cu(H2dimpy)Cl]PF6/MWCNT composite-supported electrode was characterized by electrochemical impedance spectroscopy, scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). The electrocatalytic oxidation of EP and UA using the sensor was investigated by cyclic voltammetry and square wave voltammetry. Under optimized conditions, voltammetric peak currents showed a linear response for the EP and UA concentrations in the ranges 0.5-159.2 and 0.2-58.5 µmol L−1, whereas the limits of detection were 0.2 and 0.05 µmol L−1, respectively. The sensor was successfully applied in the selective and simultaneous determination of EP and UA in human urine samples. Thus, our results showed that the supramolecular strategy was successful to build an efficient sensor for simultaneous detection of these molecules in biological samples. (AU)

FAPESP's process: 13/22127-2 - Development of novel materials strategic for integrated analytical devices
Grantee:Lauro Tatsuo Kubota
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 18/03576-4 - Mechanistic studies in water oxidation catalysis promoted by ruthenium complexes bearing imidazole units
Grantee:André Luiz Barboza Formiga
Support Opportunities: Scholarships abroad - Research
FAPESP's process: 14/50906-9 - INCT 2014: in Functional Complex Materials
Grantee:Fernando Galembeck
Support Opportunities: Research Projects - Thematic Grants