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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Malaria and tuberculosis as diseases of neglected populations: state of the art in chemotherapy and advances in the search for new drugs

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Author(s):
Renan Vinicius de Araújo [1] ; Soraya Silva Santos [2] ; Luccas Missfeldt Sanches [3] ; Jeanine Giarolla [4] ; Omar El Seoud [5] ; Elizabeth Igne Ferreira [6]
Total Authors: 6
Affiliation:
[1] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Farmácia, Laboratório de Planejamento e Síntese de Quimioterápicos Contra Doenças Negligenciadas - Brasil
[2] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Farmácia, Laboratório de Planejamento e Síntese de Quimioterápicos Contra Doenças Negligenciadas - Brasil
[3] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Farmácia, Laboratório de Planejamento e Síntese de Quimioterápicos Contra Doenças Negligenciadas - Brasil
[4] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Farmácia, Laboratório de Planejamento e Síntese de Quimioterápicos Contra Doenças Negligenciadas - Brasil
[5] Universidade de São Paulo. Instituto de Química. Departamento de Química Fundamental - Brasil
[6] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Farmácia, Laboratório de Planejamento e Síntese de Quimioterápicos Contra Doenças Negligenciadas - Brasil
Total Affiliations: 6
Document type: Journal article
Source: Memórias do Instituto Oswaldo Cruz; v. 115, 2020-10-05.
Abstract

Malaria and tuberculosis are no longer considered to be neglected diseases by the World Health Organization. However, both are huge challenges and public health problems in the world, which affect poor people, today referred to as neglected populations. In addition, malaria and tuberculosis present the same difficulties regarding the treatment, such as toxicity and the microbial resistance. The increase of Plasmodium resistance to the available drugs along with the insurgence of multidrug- and particularly tuberculosis drug-resistant strains are enough to justify efforts towards the development of novel medicines for both diseases. This literature review provides an overview of the state of the art of antimalarial and antituberculosis chemotherapies, emphasising novel drugs introduced in the pharmaceutical market and the advances in research of new candidates for these diseases, and including some aspects of their mechanism/sites of action. (AU)

FAPESP's process: 17/21154-7 - First generation polyamidoamine (PAMAM): design and synthesis of a potentially active tuberculosis prodrug
Grantee:Renan Vinicius de Araujo
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 18/10359-0 - Potentially active antimalarials against resistance: planning and synthesis of dendrons and dendrimers targeting infected erythrocytes
Grantee:Luccas Missfeldt Sanches
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 19/03018-4 - Modified PAMAM dendrimer with 4-carbomethoxypyrrolidone as a potentially tuberculostatic prodrug
Grantee:Renan Vinicius de Araujo
Support type: Scholarships abroad - Research Internship - Scientific Initiation