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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Emerging functions for ANKHD1 in cancer-related signaling pathways and cellular processes

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de Almeida, Bruna Oliveira [1] ; Machado-Neto, Joao Agostinho [1]
Total Authors: 2
[1] Univ Sao Paulo, Biomed Sci Inst, Dept Pharmacol, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: BMB REPORTS; v. 53, n. 8, p. 413-418, AUG 31 2020.
Web of Science Citations: 1

ANKHD1 (ankyrin repeat and KH domain containing 1) is a large protein characterized by the presence of multiple ankyrin repeats and a K-homology domain. Ankyrin repeat domains consist of widely existing protein motifs in nature, they mediate protein-protein interactions and regulate fundamental biological processes, while the KH domain binds to RNA or ssDNA and is associated with transcriptional and translational regulation. In recent years, studies containing relevant information on ANKHD1 in cancer biology and its clinical relevance, as well as the increasing complexity of signaling networks in which this protein ads, have been reported. Among the signaling pathways of interest in oncology regulated by ANKHD1 are Hippo signaling, JAK/STAT, and STMN1. The scope of the present review is to survey the current knowledge and highlight future perspectives for ANKHD1 in the malignant phenotype of cancer cells, exploring biological, functional, and clinical reports of this protein in cancer. (AU)

FAPESP's process: 17/24993-0 - Investigation of Stathmin 1 and microtubule instability in phenotype of hematological neoplasms
Grantee:João Agostinho Machado Neto
Support Opportunities: Regular Research Grants
FAPESP's process: 19/23864-7 - Comprehensive analysis of genomic data for identification and validation of novel therapeutic targets involved in cellular cytoskeleton regulation in acute Leukemia
Grantee:João Agostinho Machado Neto
Support Opportunities: Regular Research Grants
FAPESP's process: 19/25421-5 - Cellular and molecular evaluation of ANKHD1 silencing in breast cancer
Grantee:Bruna Oliveira de Almeida
Support Opportunities: Scholarships in Brazil - Scientific Initiation