Laser-photobiomodulation on experimental cancer pa... - BV FAPESP
Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Laser-photobiomodulation on experimental cancer pain model in Walker Tumor-256

Full text
Author(s):
Petrellis, Maria Carla [1] ; da Fonseca, Guilherme Aparecido Monteiro Duque [2] ; Pinto, Adriana de Barros [3] ; Rosa, Fernando Oliveira [4] ; Maria, Durvanei Augusto [5] ; Shibli, Jamil Awad [6] ; Frigo, Lucio [6]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Biomed Sci Inst, Dept Pharmacol, Ave Lineu Prestes 2415, BR-05508900 Sao Paulo - Brazil
[2] Univ Guarulhos, Dent Res Div, Periodontol Program, Praca Teresa Cristina 01, BR-07023070 Sao Paulo - Brazil
[3] Fac Odontol APCD, Rua Voluntarios Patria 547, BR-02011000 Sao Paulo - Brazil
[4] Univ Sao Paulo, Biomed Sci Inst, Dept Dev Cellular, Ave Lineu Prestes 2415, BR-05508900 Sao Paulo - Brazil
[5] Butantan Inst, Mol Biol Lab, Ave Dr Vital Brasil 1500, BR-05599000 Sao Paulo, SP - Brazil
[6] Univ Guarulhos, Dent Res Div, Praca Teresa Cristina 01, BR-07023070 Sao Paulo - Brazil
Total Affiliations: 6
Document type: Journal article
Source: JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY; v. 210, SEP 2020.
Web of Science Citations: 0
Abstract

Context: Cancer Pain is considered a common and significant clinical problem in malignant neoplasms, comprising 20% to 50% of all patients with tumor progression. Laser photobiomodulation (L-PBM) has been used in a multitude of pain events, ranging from acute trauma to chronic articular. However, L-PBM has never been tested in cancer pain. Objectives: Evaluate hyperalgesia, edema, COX-1, COX-2, IL-10, and Bdkrb1 mRNA in low-level laser irradiated Walker-256 tumor-bearing rats. Methods: Rat hind paw injected with Walker Tumor-256 (W-256) and divided into six groups of 6 rats: G1 (control) W-256 injected, G2W-256 + Nimesulide, G3W-256 + 1 J, G4W-256 + 3 Jand G5W256 + 6 J. Laser parameters: lambda = 660 nm, 3.57 W/cm(2), theta = 0.028 cm2. Mechanical hyperalgesia was evaluated by Randall-Selitto test. Plethysmography measured edema; mRNA levels of COX-1, COX-2, IL-10, and Bdkrb1were analyzed. Results: It was found that the W-256 + 1 J group showed a decrease in paw edema, a significant reduction in pain threshold. Higher levels of IL-10 and lower levels of COX-2 and Bdkrb1 were observed. Conclusion: Results suggest that 1 J L-PBM reduced the expression of COX-2 and Bdkrb1 and increasing IL-10 gene expression, promoting analgesia to close levels to nimesulide. (AU)