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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chemical Composition of Traditional and Analog Ayahuasca

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Kaasik, Helle [1, 2] ; Souza, Rita C. Z. [3] ; Zandonadi, Flavia S. [3] ; Tofoli, Luis Fernando [4] ; Sussulini, Alessandra [3]
Total Authors: 5
[1] Univ Tartu, Sch Theol & Religious Studies, Tartu - Estonia
[2] Univ Tartu, Inst Phys, Tartu - Estonia
[3] Univ Campinas UNICAMP, Inst Chem, Lab Bioanalyt & Integrated Omics LaBIOmics, Campinas, SP - Brazil
[4] Univ Campinas UNICAMP, Sch Med Sci, Interdisciplinary Cooperat Ayahuasca Res & Outrea, Campinas - Brazil
Total Affiliations: 4
Document type: Journal article
Source: JOURNAL OF PSYCHOACTIVE DRUGS; v. 53, n. 1 SEP 2020.
Web of Science Citations: 2

Traditional ayahuasca can be defined as a brew made from Amazonian vineBanisteriopsis caapiand Amazonian admixture plants. Ayahuasca is used by indigenous groups in Amazonia, as a sacrament in syncretic Brazilian religions, and in healing and spiritual ceremonies internationally. The study aimed to determine concentrations of the main bio- and psychoactive components of ayahuasca used in different locations and traditions. We collected 102 samples of brews from ayahuasca-using communities. Concentrations ofN,N-dimethyltryptamine (DMT), tetrahydroharmine, harmine, and harmaline were determined by ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS). Qualitative analyses for non-traditional additives (moclobemide, psilocin, yuremamine) were performed by high resolution mass spectrometry. Higher and more variable concentrations of DMT in neoshamanic ayahuasca samples compared to indigenous samples may indicate use of higher and more variable proportions of DMT-containing admixture plants. From European samples, we found two related samples of analog ayahuasca containing moclobemide, psilocin, DMT, yuremamine, and very low concentrations ofB. caapialkaloids. Some analogs of ayahuasca (Peganum harmala, Mimosa tenuiflora) were used in Europe. No analogs were found from Brazil or Santo Daime ceremonies in Europe. We recommend awareness about the constituents of the brew and ethical self-regulation among practitioners of ayahuasca ceremonies. (AU)

FAPESP's process: 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis
Grantee:Lauro Tatsuo Kubota
Support type: Research Projects - Thematic Grants
FAPESP's process: 18/01525-3 - Metabolomic studies of depression patients treated with ayahuasca
Grantee:Alessandra Sussulini
Support type: Regular Research Grants