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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Muscle Carnosine Response to Beta-Alanine Supplementation: A Systematic Review With Bayesian Individual and Aggregate Data E-Max Model and Meta-Analysis

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Rezende, Nathalia Saffioti [1] ; Swinton, Paul [2] ; de Oliveira, Luana Farias [1] ; da Silva, Rafael Pires [1] ; da Eira Silva, Vinicius [1] ; Nemezio, Kleiner [1] ; Yamaguchi, Guilherme [1] ; Artioli, Guilherme Giannini [1] ; Gualano, Bruno [3, 1] ; Saunders, Bryan [1] ; Dolan, Eimear [1]
Total Authors: 11
[1] Univ Sao Paulo, Fac Med FMUSP, Appl Physiol & Nutr Res Grp, Sch Phys Educ & Sport, Rheumatol Div, Sao Paulo - Brazil
[2] Robert Gordon Univ, Sch Hlth Sci, Aberdeen - Scotland
[3] Univ Sao Paulo, Food Res Ctr, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Review article
Source: FRONTIERS IN PHYSIOLOGY; v. 11, AUG 14 2020.
Web of Science Citations: 4

Beta-alanine (BA) supplementation increases muscle carnosine content (MCarn), and has many proven, and purported, ergogenic, and therapeutic benefits. Currently, many questions on the nature of the MCarn response to supplementation are open, and the response to these has considerable potential to enhance the efficacy and application of this supplementation strategy. To address these questions, we conducted a systematic review with Bayesian-based meta-analysis of all published aggregate data using a dose response (Emax) model. Meta-regression was used to consider the influence of potential moderators (including dose, sex, age, baseline MCarn, and analysis method used) on the primary outcome. The protocol was designed according to PRISMA guidelines and a three-step screening strategy was undertaken to identify studies that measured the MCarn response to BA supplementation. Additionally, we conducted an original analysis of all available individual data on the MCarn response to BA supplementation from studies conducted within our lab (n= 99). The Emax model indicated that human skeletal muscle has large capacity for non-linear MCarn accumulation, and that commonly used BA supplementation protocols may not come close to saturating muscle carnosine content. Neither baseline values, nor sex, appeared to influence subsequent response to supplementation. Analysis of individual data indicated that MCarn is relatively stable in the absence of intervention, and effectually all participants respond to BA supplementation (99.3% response {[}95%CrI: 96.2-100]). (AU)

FAPESP's process: 13/14746-4 - Carnosine metabolism in skeletal muscle: a multi-approach study
Grantee:Bruno Gualano
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 17/04973-4 - Nutritional supplementation and exercise to optimise exercise performance: focus on individual responses and a step towards personalized sports nutrition
Grantee:Bryan Saunders
Support Opportunities: Scholarships in Brazil - Young Researchers
FAPESP's process: 17/09635-0 - Factors determining the carnosine content of human skeletal muscle: Influence of age and sex
Grantee:Eimear Bernadette Dolan
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 15/23176-2 - The kinetics of muscle carnosine washout after beta-alanine supplementation
Grantee:Guilherme de Carvalho Yamaguchi
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 19/27758-7 - To investigate the relationship between pH and bone metabolic markers during a prolonged exercise test interspersed with high-intensity sprints
Grantee:Nathália Saffioti Rezende
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 19/05616-6 - The bone response to exercise: a translational research program exploring clinical and mechanistic aspects
Grantee:Eimear Bernadette Dolan
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 17/23688-9 - High-intensity intermittent training and beta-alanine supplementation: effects on carnosine metabolism in skeletal muscle and exercise performance and capacity
Grantee:Rafael Pires da Silva
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 14/11948-8 - Life without carnosine: development and characterization of a KO rat model for studying the physiological role of carnosine and its implications to physical exercise and muscle metabolism
Grantee:Guilherme Giannini Artioli
Support Opportunities: Research Grants - Young Investigators Grants