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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chitosan hydrogel covalently crosslinked by gold nanoparticle: Eliminating the use of toxic crosslinkers

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Tenorio, Fernanda Silva [1] ; do Amaral Montanheiro, Thais Larissa [2] ; Isaias dos Santos, Alexandre Martins [1] ; Silva, Mateus dos Santos [3] ; Lemes, Ana Paula [3] ; Tada, Dayane Batista [1]
Total Authors: 6
[1] Univ Fed Sao Paulo, Lab Nanomat & Nanotoxicol, Talim 330, BR-12231280 Sao Jose Dos Campos, SP - Brazil
[2] Inst Tecnol Aeronaut, Lab Plasmas & Proc, Sao Jose Dos Campos, SP - Brazil
[3] Univ Fed Sao Paulo, Polymer & Biopolymer Technol Lab, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Applied Polymer Science; v. 138, n. 6 AUG 2020.
Web of Science Citations: 0

Tissue engineering has directed a lot of effort toward the development of devices with suitable biocompatibility and mechanical properties. Chitosan has been pointed as a valuable material to be applied in scaffolds due to its antimicrobial activity and biocompatibility. Nevertheless, the low mechanical resistance associated with the requirement of toxic crosslinkers has hampered translational application of chitosan hydrogel. Herein, the use of gold nanoparticles (AuNP) as crosslinker is reported as a great strategy to obtain chitosan hydrogel without using toxic reactants. In addition, the resultant chitosan hydrogel, crosslinked by AuNP of 30 nm (AuNP30), presented outstanding properties compared to chitosan hydrogel crosslinked by glutaraldehyde. Chitosan hydrogel crosslinked by AuNP30 presented lower porosity, which provided lower swelling degree and slower degradation rate. In addition, compressive strength was about two times higher than the chitosan hydrogel crosslinked by glutaraldehyde. The crosslink by AuNP30 also increased the biocompatibility of the hydrogel. Chitosan hydrogel crosslinked by AuNP30 did not show cytotoxicity against MEF cells, whereas cell viability of cells incubated with extract from chitosan hydrogel crosslinked by glutaraldehyde was only 41%. In conclusion, the results reported herein pointed that the use of AuNP30 as crosslinker agent provided to chitosan hydrogel enhanced properties that made it suitable to application in biomedical devices. (AU)

FAPESP's process: 17/01697-6 - Synthesis and functionalization of bimetallic nanoparticles for application in photodynamic therapy of cancer
Grantee:Dayane Batista Tada
Support type: Regular Research Grants
FAPESP's process: 17/24873-4 - PHBV and hydroxybutyrate functionalized CNT nanocomposite: kinetic study of crystallization and correlation with mechanical properties
Grantee:Thaís Larissa do Amaral Montanheiro
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/27064-9 - Utilization of cellulose nanocrystals in the production of polymer nanocomposites for applications in the medical area
Grantee:Ana Paula Lemes
Support type: Regular Research Grants