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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Precision non-implantable neuromodulation therapies: a perspective for the depressed brain

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Author(s):
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Borrione, Lucas [1] ; Bellini, Helena [1] ; Razza, Lais Boralli [1] ; Avila, Ana G. [2] ; Baeken, Chris [3, 4, 5, 6] ; Brem, Anna-Katharine [7, 8] ; Busatto, Geraldo [9] ; Carvalho, Andre F. [10, 11] ; Chekroud, Adam [12, 13] ; Daskalakis, Zafiris J. [10, 11] ; Deng, Zhi-De [14, 15] ; Downar, Jonathan [16, 17, 18] ; Gattaz, Wagner [19, 20] ; Loo, Colleen [21, 22] ; Lotufo, Paulo A. [23] ; Martin, Maria da Graca M. [24, 25] ; McClintock, Shawn M. [26] ; O'Shea, Jacinta [27] ; Padberg, Frank [28] ; Passos, Ives C. [29, 30] ; Salum, Giovanni A. [31] ; Vanderhasselt, Marie-Anne [3, 4, 32] ; Fraguas, Renerio [33, 9] ; Bensenor, Isabela [23] ; Valiengo, Leandro [1] ; Brunoni, Andre R. [33, 1, 19, 20]
Total Authors: 26
Affiliation:
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[1] Univ Sao Paulo, Fac Med, Hosp Clin, Serv Interdisciplinar Neuromodulacao, Dept & Inst Psiquiatria, Lab Neurociencias LIM 27, Sao Paulo, SP - Brazil
[2] Univ Coimbra, Fac Psicol & Ciencias Educ, Ctr Neuropsicol & Intervencao Cognit Comportament, Coimbra - Portugal
[3] Univ Ghent, Fac Med & Hlth Sci, Dept Head & Skin, Ghent - Belgium
[4] Univ Ghent, Ghent Expt Psychiat GHEP Lab, Ghent - Belgium
[5] Univ Hosp UZ Brussel, Dept Psychiat, Brussels - Belgium
[6] Eindhoven Univ Technol, Dept Elect Engn, Eindhoven - Netherlands
[7] Max Planck Inst Psychiat, Munich - Germany
[8] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Berenson Allen Ctr Noninvas Brain Stimulat, Dept Neurol, Div Intervent Cognit Neurol, Boston, MA 02115 - USA
[9] Univ Sao Paulo, Fac Med, Hosp Clin, Dept & Inst Psiquiatria, Lab Neuroimagem Psiquiatr, Sao Paulo, SP - Brazil
[10] Univ Toronto, Dept Psychiat, Toronto, ON - Canada
[11] Ctr Addict & Mental Hlth CAMH, Toronto, ON - Canada
[12] Yale Univ, Dept Psychiat, New Haven, CT 06520 - USA
[13] Spring Hlth, New York, NY - USA
[14] NIMH, Noninvas Neuromodulat Unit, Expt Therapeut & Pathophysiol Branch, NIH, Bethesda, MD 20892 - USA
[15] Duke Univ, Sch Med, Dept Psychiat & Behav Sci, Durham, NC - USA
[16] Univ Hlth Network, Krembil Res Inst, Toronto, ON - Canada
[17] Univ Toronto, Fac Med, Dept Psychiat & Inst Med Sci, Toronto, ON - Canada
[18] Univ Hlth Network, Ctr Mental Hlth, Toronto, ON - Canada
[19] Univ Sao Paulo, Fac Med, Hosp Clin, Dept & Inst Psiquiatria, Lab Neurociencias LIM 27, Sao Paulo, SP - Brazil
[20] Univ Sao Paulo, Fac Med, Hosp Clin, Dept & Inst Psiquiatria, Inst Nacl Biomarcadores N, Sao Paulo, SP - Brazil
[21] Univ New South Wales, Sch Psychiat, Sydney, NSW - Australia
[22] Univ New South Wales, Black Dog Inst, Sydney, NSW - Australia
[23] Univ Sao Paulo, Hosp Univ, Ctr Pesquisa Clin & Epidemiol, Estudo Longitudinal Saude Adulto ELSA, Sao Paulo, SP - Brazil
[24] Univ Sao Paulo, Fac Med, Hosp Clin, Lab Ressonancia Magnet Neurorradiol LIM 44, Sao Paulo, SP - Brazil
[25] Univ Sao Paulo, Fac Med, Hosp Clin, Inst Radiol, Sao Paulo, SP - Brazil
[26] UT Southwestern Med Ctr, Dept Psychiat, Neurocognit Res Lab, Dallas, TX - USA
[27] Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford Ctr Human Brain Act, Wellcome Ctr Integrat, Oxford - England
[28] Univ Hosp, Dept Psychiat & Psychotherapy, LMU Munich, Munich - Germany
[29] Univ Fed Rio Grande do Sul UFRGS, Programa Posgrad Psiquiatria & Ciencias Comportam, Hosp Chn Porto Alegre HCPA, Lab Psiquiatria Mol, Porto Alegre, RS - Brazil
[30] Univ Fed Rio Grande do Sul UFRGS, Programa Posgrad Psiquiatria & Ciencias Comportam, Hosp Chn Porto Alegre HCPA, Programa Transtorno Bipolar, Porto Alegre, RS - Brazil
[31] Univ Fed Rio Grande do Sul, HCPA, Secao Afeto Negat & Proc Sociais SANPS, Dept Psiquiatria, Porto Alegre, RS - Brazil
[32] Univ Ghent, Dept Expt Clin & Hlth Psychol, Psychopathol & Affect Neurosci Lab, Ghent - Belgium
[33] Univ Sao Paulo, Hosp Univ, Sao Paulo, SP - Brazil
Total Affiliations: 33
Document type: Journal article
Source: Revista Brasileira de Psiquiatria; v. 42, n. 4, p. 403-419, JUL-AUG 2020.
Web of Science Citations: 1
Abstract

Current first-line treatments for major depressive disorder (MDD) include pharmacotherapy and cognitive-behavioral therapy. However, one-third of depressed patients do not achieve remission after multiple medication trials, and psychotherapy can be costly and time-consuming. Although non-implantable neuromodulation (NIN) techniques such as transcranial magnetic stimulation, transcranial direct current stimulation, electroconvulsive therapy, and magnetic seizure therapy are gaining momentum for treating MDD, the efficacy of non-convulsive techniques is still modest, whereas use of convulsive modalities is limited by their cognitive side effects. In this context, we propose that NIN techniques could benefit from a precision-oriented approach. In this review, we discuss the challenges and opportunities in implementing such a framework, focusing on enhancing NIN effects via a combination of individualized cognitive interventions, using closed-loop approaches, identifying multimodal biomarkers, using computer electric field modeling to guide targeting and quantify dosage, and using machine learning algorithms to integrate data collected at multiple biological levels and identify clinical responders. Though promising, this framework is currently limited, as previous studies have employed small samples and did not sufficiently explore pathophysiological mechanisms associated with NIN response and side effects. Moreover, cost-effectiveness analyses have not been performed. Nevertheless, further advancements in clinical trials of NIN could shift the field toward a more ``precision-oriented{''} practice. (AU)

FAPESP's process: 19/07256-7 - Cerebral alteration perfusion induced by transcranial stimulation of the prefrontal cortex: a randomized, placebo-controlled study, using 99mTc SPECT
Grantee:Lais Boralli Razza
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)