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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The P2X7 Receptor: Central Hub of Brain Diseases

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Andrejew, Roberta [1] ; Oliveira-Giacomelli, Agatha [1] ; Ribeiro, Deidiane Elisa [1] ; Glaser, Talita [1] ; Arnaud-Sampaio, Vanessa Fernandes [1] ; Lameu, Claudiana [1] ; Ulrich, Henning [1]
Total Authors: 7
[1] Univ Sao Paulo, Inst Chem, Dept Biochem, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Web of Science Citations: 0

The P2X7 receptor is a cation channel activated by high concentrations of adenosine triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming a wide pore that leads to cell death and increased release of ATP into the extracellular milieu. The P2X7 receptor is widely expressed in the CNS, such as frontal cortex, hippocampus, amygdala and striatum, regions involved in neurodegenerative diseases and psychiatric disorders. Despite P2X7 receptor functions in glial cells have been extensively studied, the existence and roles of this receptor in neurons are still controversially discussed. Regardless, P2X7 receptors mediate several processes observed in neuropsychiatric disorders and brain tumors, such as activation of neuroinflammatory response, stimulation of glutamate release and neuroplasticity impairment. Moreover, P2X7 receptor gene polymorphisms have been associated to depression, and isoforms of P2X7 receptors are implicated in neuropsychiatric diseases. In view of that, the P2X7 receptor has been proposed to be a potential target for therapeutic intervention in brain diseases. This review discusses the molecular mechanisms underlying P2X7 receptor-mediated signaling in neurodegenerative diseases, psychiatric disorders, and brain tumors. In addition, it highlights the recent advances in the development of P2X7 receptor antagonists that are able of penetrating the central nervous system. (AU)

FAPESP's process: 15/13345-1 - Huntington's disease: Huntingtin roles during cell fate decision
Grantee:Talita Glaser
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 18/17504-5 - Behavioral and molecular effects of pharmacological modulation of the P2Y2 receptors in an animal model of Alzheimer's Disease
Grantee:Deidiane Elisa Ribeiro
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 19/24553-5 - The role of P2Y1 receptor in Parkinsons Disease
Grantee:Roberta Andrejew Caetano
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/19128-2 - Metastasis mechanisms of childhood tumors to bone marrow
Grantee:Claudiana Lameu
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 18/07366-4 - Purine and kinin receptors as targets of study and therapeutic interventions in neurological diseases
Grantee:Alexander Henning Ulrich
Support type: Research Projects - Thematic Grants