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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Neuroinflammation, Pain and Depression: An Overview of the Main Findings

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Pinheiro Campos, Ana Carolina [1] ; Antunes, Geiza Fernanda [1] ; Matsumoto, Marcio [2] ; Pagano, Rosana Lima [1] ; Ruiz Martinez, Raquel Chacon [1, 3]
Total Authors: 5
[1] Hosp Sirio Libanes, Div Neurosci, Sao Paulo - Brazil
[2] Hosp Sirio Libanes, Anesthesiol Med Ctr, Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Psychiat, Sch Med, LIM 23, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Review article
Source: FRONTIERS IN PSYCHOLOGY; v. 11, JUL 31 2020.
Web of Science Citations: 0

Chronic pain is a serious public health problem with a strong affective-motivational component that makes it difficult to treat. Most patients with chronic pain suffer from severe depression; hence, both conditions coexist and exacerbate one another. Brain inflammatory mediators are critical for maintaining depression-pain syndrome and could be substrates for it. The goal of our paper was to review clinical and preclinical findings to identify the neuroinflammatory profile associated with the cooccurrence of pain and depression. In addition, we aimed to explore the regulatory effect of neuronal reorganization on the inflammatory response in pain and depression. We conducted a quantitative review supplemented by manual screening. Our results revealed inflammatory signatures in different preclinical models and clinical articles regarding depression-pain syndrome. We also identified that improvements in depressive symptoms and amelioration of pain can be modulated through direct targeting of inflammatory mediators, such as cytokines and molecular inhibitors of the inflammatory cascade. Additionally, therapeutic targets that improve and regulate the synaptic environment and its neurotransmitters may act as anti-inflammatory compounds, reducing local damage-associated molecular patterns and inhibiting the activation of immune and glial cells. Taken together, our data will help to better elucidate the neuroinflammatory profile in pain and depression and may help to identify pharmacological targets for effective management of depression-pain syndrome. (AU)

FAPESP's process: 18/18695-9 - Deep brain stimulation and Parkinsons Disease: neuroinflammation control as therapeutic target
Grantee:Ana Carolina Pinheiro Campos
Support type: Scholarships in Brazil - Doctorate (Direct)