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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Impact of Modality and Intensity of Early Exercise Training on Ventricular Remodeling after Myocardial Infarction

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Batista, Diego Fernando [1] ; Polegato, Bertha Furlan [1] ; da Silva, Renata Candido [1] ; Claro, Renan Turini [1] ; Azevedo, Paula Shmidt [1] ; Fernandes, Ana Angelica [2] ; Okoshi, Katashi [1] ; de Paiva, Sergio Alberto Rupp [1] ; Minicucci, Marcos Ferreira [1] ; Zornorff, Leonardo Antonio Mamede [1]
Total Authors: 10
[1] Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Internal Med, Botucatu, SP - Brazil
[2] Sao Paulo State Univ UNESP, Dept Chem & Biochem, Inst Biosci Botucatu, Botucatu, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Web of Science Citations: 0

The objective of this study was to analyze the impact of different modalities and intensities of exercise training on cardiac remodeling started early after experimental myocardial infarction (MI). Male Wistar rats, weighing 200-250 g, were subjected to experimental MI. After 5 days, the animals were allocated into three experimental groups and observed for three months: S (sedentary control animals), C (animals subjected to continuous low-intensity training), and HIT (animals subjected to high-intensity interval training). Low-intensity exercise training was performed at a treadmill speed corresponding to 40% VO(2)max, which was kept unchanged throughout the entire session (i.e., continuous low-intensity training). High-intensity interval training was performed in such a way that rats run during 3 min at 60% VO(2)max, followed by 4-minute intervals at 85% VO(2)max (i.e., high-intensity interval training). After the follow-up period, we studied hypertrophy and ventricular geometry, functional alterationsin vivoandin vitro, oxidative stress, apoptosis, and cardiac energetic metabolism. Our data showed that both high-intensity interval and continuous low-intensity modalities improved cardiac energetic metabolism variables in comparison with sedentary infarcted animals. In addition, high-intensity interval training decreased cardiac oxidative stress, associated with improved diastolic function. On the other hand, the continuous low-intensity group showed impairment of cardiac function. Therefore, altogether, our data suggest that high-intensity interval training could be the best modality for early physical exercise after MI and should be better studied in this clinical scenario. (AU)

FAPESP's process: 18/20790-0 - Role of netosis as modulator of doxorubicin-induced cardiotoxicity
Grantee:Leonardo Antonio Mamede Zornoff
Support Opportunities: Regular Research Grants
FAPESP's process: 12/22051-3 - Impact of exercise intensity early after myocardial infarction in the cardiac remodeling process
Grantee:Diego Fernando Batista
Support Opportunities: Scholarships in Brazil - Doctorate