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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Correlations among vitamin K intake, body fat, lipid profile and glucose homeostasis in adults and the elderly

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Author(s):
Elizabete A. dos Santos [1] ; Kelly V. Giudici [2] ; Natasha A. G. de França [3] ; Barbara S. Emo Peters [4] ; Regina Mara Fisberg [5] ; Lígia A. Martini [6]
Total Authors: 6
Affiliation:
[1] Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Nutrição - Brasil
[2] Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Nutrição - Brasil
[3] Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Nutrição - Brasil
[4] Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Nutrição - Brasil
[5] Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Nutrição - Brasil
[6] Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Nutrição - Brasil
Total Affiliations: 6
Document type: Journal article
Source: ARCHIVES OF ENDOCRINOLOGY METABOLISM; v. 64, n. 4, p. 436-444, 2020-04-06.
Abstract

ABSTRACT Objective Recent research has investigated the possible inverse relationship between vitamin K intake and body fat. In addition, an increasing number of studies are supporting a key role for this vitamin in improving lipid profile and insulin sensitivity and reducing the risk of type 2 diabetes mellitus, but little is known about what mechanisms would be involved. Thus, the objective of this study was to investigate the relationship between vitamin K intake (in the form of phylloquinone – PK), body fat, lipid profile and markers of glucose homeostasis in adults and the elderly. Subjects and methods A cross-sectional study with 298 participants (46% men) in the São Paulo Health Survey 2014-2015. Spearman correlations were performed to evaluate the associations between vitamin K intake and the biochemical and body composition measures. Results Among normal-weight male adults (n = 15), PK intake presented a positive correlation with the quantitative insulin sensitivity check index (QUICKI) (r = 0.525; p = 0.045). Among men with high fat mass index (FMI) (n = 101), PK intake had a negative correlation with homeostasis model assessment estimate for β-cell function (HOMA-β) (r = −0.227; p = 0.022). In women with high FMI (n = 122), PK intake had a negative correlation with HOMA-β (r = −0.199, p = 0.032) and insulin (r = −0.207, p = 0.026). No correlations were found between PK intake and lipid profile. Conclusions Our findings support a potential relationship among PK intake, body fat and markers of glucose homeostasis in adults and the elderly. (AU)

FAPESP's process: 12/22113-9 - Biochemical indicators of micronutrient status and usual intakes of residents from the City of São Paulo - ISA-Capital Survey 2013
Grantee:Regina Mara Fisberg
Support type: Regular Research Grants
FAPESP's process: 15/07971-7 - Osteosarcopenic obesity: Crosstalk between osteoporosis, vitamin D, dietary intake and bone fracture risk
Grantee:Lígia Araújo Martini
Support type: Regular Research Grants