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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Candida-Associated Denture Stomatitis and Murine Models: What Is the Importance and Scientific Evidence?

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Campos Sugio, Carolina Yoshi [1] ; Maia Neves Garcia, Amanda Aparecida [1] ; Albach, Thais [2] ; Moraes, Gustavo Simao [2] ; Bonfante, Estevam Augusto [1] ; Urban, Vanessa Migliorini [2] ; Neppelenbroek, Karin Hermana [1]
Total Authors: 7
[1] Univ Sao Paulo, Bauru Sch Dent, Dept Prosthodont & Periodont, Alameda Octavio Pinheiro Brisolla 9-75, BR-17012901 Bauru, SP - Brazil
[2] Univ Estadual Ponta Grossa, Dept Dent, Ave Gen Carlos Cavalcanti 4748, BR-84030900 Ponta Grossa, PR - Brazil
Total Affiliations: 2
Document type: Review article
Source: JOURNAL OF FUNGI; v. 6, n. 2 JUN 2020.
Web of Science Citations: 0

Considering the high prevalence and recurrence ofCandida-associated denture stomatitis (CADS), in vivo studies in animal models are necessary before those in humans to evaluate new therapeutic strategies. This study aimed to review the literature on murine models of CADS induction using acrylic intraoral devices simulating dentures. Rats are recommended as experimental animals in these models as well as the adoption of a pasty diet. For maintenance in the proper position during the experiments, intraoral appliances must be obtained by individual impressions, using and retained exclusively by cementation on the molars. The region of interest for histopathological analysis was standardized as that corresponding to the area between the first molars. However, there is no consensus among the studies on the CADS induction rat models in relation to theCandida albicansinoculation and need for immunosuppression and/or administration of antibacterial drugs of animals. The greatest difficulty of the available models refers to maintaining the course of the lesion for a sufficient period to evaluate the effectiveness of the proposed treatment, considering the rapid and efficient murine immune response to candidal colonization. Therefore, future studies are necessary for the development of a robust and reproducible CADS model. (AU)

FAPESP's process: 17/07314-1 - Clinical evaluation of antifungal addition to temporary soft liner in the treatment of denture stomatitis
Grantee:Karin Hermana Neppelenbroek
Support Opportunities: Regular Research Grants
FAPESP's process: 17/22996-1 - Tissue response in animal model of tissue conditioner containing inclusion complex antifungal:²-cyclodextrin for denture stomatitis treatment
Grantee:Carolina Yoshi Campos Sugio
Support Opportunities: Scholarships in Brazil - Master