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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Formulating SLN and NLC as Innovative Drug Delivery Systems for Non-Invasive Routes of Drug Administration

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Fonseca-Santos, Bruno [1] ; Silva, Patricia Bento [2] ; Rigon, Roberta Balasin [3] ; Sato, Mariana Rillo [1] ; Chorilli, Marius [1]
Total Authors: 5
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Med, BR-14801903 Araraquara, SP - Brazil
[2] Univ Brasilia UnB, Dept Genet & Morphol, BR-70910970 Brasilia, DF - Brazil
[3] Univ Campinas UNICAMP, Fac Pharmaceut Sci, BR-13083871 Campinas, SP - Brazil
Total Affiliations: 3
Document type: Review article
Source: Current Medicinal Chemistry; v. 27, n. 22, p. 3623-3656, 2020.
Web of Science Citations: 1

Colloidal carriers diverge depending on their composition, ability to incorporate drugs and applicability, but the common feature is the small average particle size. Among the carriers with the potential nanostructured drug delivery application there are SLN and NLC. These nanostructured systems consist of complex lipids and highly purified mixtures of glycerides having varying particle size. Also, these systems have shown physical stability, protection capacity of unstable drugs, release control ability, excellent tolerability, possibility of vectorization, and no reported production problems related to large-scale. Several production procedures can be applied to achieve high association efficiency between the bioactive and the carrier, depending on the physicochemical properties of both, as well as on the production procedure applied. The whole set of unique advantages such as enhanced drug loading capacity, prevention of drug expulsion, leads to more flexibility for modulation of drug release and makes Lipid-based nanocarriers (LNCs) versatile delivery system for various routes of administration. The route of administration has a significant impact on the therapeutic outcome of a drug. Thus, the non-invasive routes, which were of minor importance as parts of drug delivery in the past, have assumed added importance drugs, proteins, peptides and biopharmaceuticals drug delivery and these include nasal, buccal, vaginal and transdermal routes. The objective of this paper is to present the state of the art concerning the application of the lipid nanocarriers designated for non-invasive routes of administration. In this manner, this review presents an innovative technological platform to develop nanostructured delivery systems with great versatility of application in non-invasive routes of administration and targeting drug release. (AU)

FAPESP's process: 13/09265-7 - Evaluation of the potential nanostructured lipid systems for administration of Cu(II) compounds applicable in optimizing the treatment of tuberculosis
Grantee:Patrícia Bento da Silva
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 16/11198-4 - Nanostructured lipid carriers dispersed in situ gelling hydrogel for vaginal administration of hypericin associated with photodynamic therapy in the treatment of vulvovaginal candidiasis
Grantee:Mariana Rillo Sato
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/05394-2 - Evaluating the potential of nanostructured surfactant-based systems to intranasal administration of trans-resveratrol in the optimization of Alzheimer's disease therapy
Grantee:Bruno da Fonseca dos Santos
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/24180-0 - Liquid crystalline systems as potential strategy ofr incorporation of trans-resveratrol: development, physicochemical characterization and in vitro and in vivo biological assays
Grantee:Marlus Chorilli
Support type: Regular Research Grants
FAPESP's process: 13/21500-1 - Solid lipid nanoparticles for incorporation of trans-resveratrol in the topical treatment of melanoma: in vitro and in vivo evaluation and the elucidation of the mechanism of uptake cellular
Grantee:Roberta Balansin Rigon
Support type: Scholarships in Brazil - Doctorate