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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

3D Modeling of Dendritic Spines with Synaptic Plasticity

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Antunes, Gabriela [1] ; Simoes de Souza, Fabio M. [1]
Total Authors: 2
[1] Fed Univ ABC, Ctr Math Computat & Cognit, Santo Andre, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Web of Science Citations: 0

Computational modeling of diffusion and reaction of chemical species in a three-dimensional (3D) geometry is a fundamental method to understand the mechanisms of synaptic plasticity in dendritic spines. In this protocol, the detailed 3D structure of the dendrites and dendritic spines is modeled with meshes on the software Blender with CellBlender. The synaptic and extrasynaptic regions are defined on the mesh. Next, the synaptic receptor and synaptic anchor molecules are defined with their diffusion constants. Finally, the chemical reactions between synaptic receptors and synaptic anchors are included and the computational model is solved numerically with the software MCell. This method describes the spatiotemporal path of every single molecule in a 3D geometrical structure. Thus, it is very useful to study the trafficking of synaptic receptors in and out of the dendritic spines during the occurrence of synaptic plasticity. A limitation of this method is that the high number of molecules slows the speed of the simulations. Modeling of dendritic spines with this method allows the study of homosynaptic potentiation and depression within single spines and heterosynaptic plasticity between neighbor dendritic spines. (AU)

FAPESP's process: 16/18825-4 - Computing language with mirror neurons
Grantee:Fábio Marques Simões de Souza
Support Opportunities: Research Grants - Research Partnership for Technological Innovation - PITE
FAPESP's process: 18/06504-4 - The role of mirror neurons in addiction: a cross linguistic study in Iran and Brazil
Grantee:Fábio Marques Simões de Souza
Support Opportunities: Regular Research Grants
FAPESP's process: 15/50122-0 - Dynamic phenomena in complex networks: basics and applications
Grantee:Elbert Einstein Nehrer Macau
Support Opportunities: Research Projects - Thematic Grants