Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Radiation-related caries: current diagnostic, prognostic, and management paradigms

Full text
Palmier, Natalia Rangel [1] ; Migliorati, Cesar Augusto [2] ; Prado-Ribeiro, Ana Carolina [3] ; Querido de Oliveira, Maria Cecilia [3] ; Vechiato Filho, Aljomar Jose [3] ; de Goes, Mario Fernando [4] ; Brandao, Thais Bianca [3] ; Lopes, Marcio Ajudarte [1] ; Santos-Silva, Alan Roger [1]
Total Authors: 9
[1] Univ Estadual Campinas, Piracicaba Dent Sch, Oral Diag, Piracicaba, SP - Brazil
[2] Univ Florida, Coll Dent, Gainesville, FL - USA
[3] ICESP FMUSP, Dent Oncol Serv, Sao Paulo State Canc Inst, Sao Paulo, SP - Brazil
[4] Univ Estadual Campinas, Restorat Dent Dept, Piracicaba Dent Sch, Piracicaba, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Web of Science Citations: 0

Objective and study design. This narrative review summarizes the current state of art of radiation-related caries (RC), an aggressive disease that affects approximately 30% of post-head and neck radiotherapy (HNRT) patients. Results. RC mainly affects the tooth cervical areas and incisal/cuspal tips and develops 6 to 12 months after HNRT. Early RC signs include black/brownish tooth discoloration and enamel cracks, which progress to enamel delamination, exposing underlying dentin to a highly cariogenic oral environment and rapid tooth destruction/dental crown amputation. As RC advances and renders the tooth nonrestorable, it may lead to osteoradionecrosis spontaneously or upon extraction if the tooth is in a highly irradiated field of the oral cavity. This requires aggressive treatment, which would have a negative impact on a cancer survivor's quality of life and contribute to the incremental cost of cancer care. Chlorhexidine mouth rinses and topical fluoride applications are effective agents used in RC prevention; however, there are no well-established treatment protocols. Once RC progresses, dental restorations should be performed with adhesive materials in association with systematic fluoride application as illustrated in the clinical case presented in this review. Post-HNRT patients should be closely followed up for optimal RC prevention, early diagnosis, and prompt treatment. Conclusions. Future clinical studies are necessary to establish a contemporary, clinically validated protocol for RC management. (AU)

FAPESP's process: 18/02233-6 - Oncological safety of the use of intraoral and extraoral photobiomodulation in patients with oral cavity and oropharyngeal squamous cell carcinoma
Grantee:Alan Roger dos Santos Silva
Support type: Regular Research Grants
FAPESP's process: 12/06138-1 - A prospective study of radiation-induced trismus in patients with oral squamous cell carcinoma
Grantee:Ana Carolina Prado Ribeiro e Silva
Support type: Regular Research Grants
FAPESP's process: 13/18402-8 - Evaluation of the direct effects of radiation on the enamel, dentin and dental pulp of head and neck cancer patients
Grantee:Alan Roger dos Santos Silva
Support type: Regular Research Grants
FAPESP's process: 16/22862-2 - Impact of age in radiation-induced oral toxicities of young patients with oral cancer
Grantee:Jaqueline de Lima Correia
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 18/04657-8 - Salivary protein markers of radiation-related oral toxicites
Grantee:Natália Rangel Palmier
Support type: Scholarships in Brazil - Doctorate