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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Caffeine reduces the toxicity of albendazole and carbamazepine to the microalgaeRaphidocelis subcapitata(Sphaeropleales, Chlorophyta)

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Diniz, Vinicius [1] ; Reyes, Gabriela M. [2] ; Rath, Susanne [2] ; Cunha, Davi G. F. [1]
Total Authors: 4
[1] Univ Sao Paulo, Dept Hidraul & Saneamento, Escola Engn Sao Carlos, Ave Trab Sao Carlense, 400 Parque Arnold Schimidt, BR-13566590 Sao Carlos, SP - Brazil
[2] Univ Estadual Campinas, Inst Chem, Campinas - Brazil
Total Affiliations: 2
Document type: Journal article
Web of Science Citations: 0

Pharmaceutically active compounds (PhACs) are emerging contaminants that have been widely detected in water bodies in the last decades, with ecological effects toward aquatic biota that have not been fully elucidated. Most studies concerning their toxicity to microalgae have only considered short-term individual PhAC exposure, rather than combined exposure to several compounds for longer time periods. In this study, we investigated the effects of albendazole (ABZ) (anthelmintic) and carbamazepine (antiepileptic), alone and in combination with caffeine, on the growth and production of chlorophyll-a of the microalgaeRaphidocelis subcapitata, during 16 days of exposure. ABZ alone had a more significant effect than carbamazepine alone on the growth rate and maximum cell density of the microalgae (p < .05; analysis of variance). These results were probably related to the effect of ABZ in inhibiting enzyme complexes and cell membrane proteins related to adenosine triphosphate synthesis, which is important for cell growth. The presence of caffeine lowered the toxicities of ABZ and carbamazepine to the microalgae, probably due to its antioxidant properties, positively affecting chlorophyll-a production, growth rate, and maximum cell density. Thus, caffeine had an antagonistic interaction with the studied PhACs. The results reinforce the importance of ecotoxicological assays that compare individual and combined PhAC exposure conditions. Our findings highlighted that caffeine can be a relevant factor influencing such assays, considering its widespread occurrence in impacted water bodies. (AU)

FAPESP's process: 18/03571-2 - Pharmaceuticals in the Aquatic Environment.
Grantee:Susanne Rath
Support type: Regular Research Grants