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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Aerobic training prevents cardiometabolic changes triggered by myocardial infarction in ovariectomized rats

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Author(s):
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Ruberti, Olivia Moraes [1] ; Sousa, Andressa Silva [1] ; Viana, Lais Rosa [1] ; Gomes, Moises Felipe Pereira [2] ; Medeiros, Alessandra [2] ; Marcondes, Maria Cristina Cintra Gomes [1] ; Borges, Luciano de Figueiredo [2] ; Crestani, Carlos Cesar [3] ; Mostarda, Cristiano [4] ; Moraes, Telma Fatima da Cunha [5] ; Canevarolo, Rafael Renatino [6] ; Delbin, Maria Andreia [1] ; Rodrigues, Bruno [1, 7]
Total Authors: 13
Affiliation:
[1] Univ Campinas UNICAMP, Inst Biol, Dept Struct & Funct Biol, Campinas, SP - Brazil
[2] Fed Univ Sao Paulo UNIFESP, Dept Biosci, Santos, SP - Brazil
[3] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Lab Pharmacol, Araraquara, SP - Brazil
[4] Fed Univ Maranhao UFMA, Dept Phys Educ, Sao Luis, MA - Brazil
[5] Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo, SP - Brazil
[6] H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Physiol, Tampa, FL - USA
[7] Univ Campinas UNICAMP, Sch Phys Educ, Dept Adapted Phys Act, Campinas, SP - Brazil
Total Affiliations: 7
Document type: Journal article
Source: Journal of Cellular Physiology; v. 236, n. 2 JUL 2020.
Web of Science Citations: 0
Abstract

This study aimed to evaluate the impact of aerobic training (AT) on autonomic, cardiometabolic, ubiquitin-proteasome activity, and inflammatory changes evoked by myocardial infarction (MI) in ovariectomized rats. Female Wistar rats were ovariectomized and divided into four groups: sedentary + sham (SS), sedentary + MI (SI), AT + sham surgery (TS), AT + MI (TI). AT was performed on a treadmill for 8 weeks before MI. Infarcted rats previously subjected to AT presented improved physical capacity, increased interleukin-10, and decreased pro-inflammatory cytokines. Metabolomic analysis identified and quantified 62 metabolites, 9 were considered significant by the Vip Score. SS, SI, and TS groups presented distinct metabolic profiles; however, TI could not be distinguished from the SS group. MI dramatically increased levels of dimethylamine, and AT prevented this response. Our findings suggest that AT may be useful in preventing the negative changes in functional, inflammatory, and metabolic parameters related to MI in ovariectomized rats. (AU)

FAPESP's process: 13/14788-9 - Effects of exercise training and cholinergic stimulation with pyridostigmine bromide before and after myocardial infarction: role on cardiac and autonomic function, and inflammatory profile
Grantee:Bruno Rodrigues
Support Opportunities: Regular Research Grants