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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genetic polymorphisms in theInterleukins IL1B, IL4,andIL6are associated with concomitant periodontitis and type 2 diabetes mellitus in Brazilian patients

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Cirelli, Thamiris [1, 2] ; Nepomuceno, Rafael [1, 2] ; Rios, Ana Claudia S. [2] ; Orrico, Silvana R. P. [1, 3] ; Cirelli, Joni A. [1] ; Theodoro, Leticia H. [4] ; Barros, Silvana P. [5] ; Scarel-Caminaga, Raquel M. [2]
Total Authors: 8
[1] Sao Paulo State Univ UNESP, Sch Dent Araraquara, Dept Diag & Surg, Araraquara, SP - Brazil
[2] Sao Paulo State Univ UNESP, Sch Dent Araraquara, Dept Morphol Genet Orthodont & Pediat Dent, Araraquara, SP - Brazil
[3] Union Coll Great Lakes UNILAGO, Adv Res Ctr Med, Sao Jose Do Rio Preto - Brazil
[4] Sao Paulo State Univ UNESP, Sch Dent Aracatuba, Dept Surg & Integrated Clin, Aracatuba - Brazil
[5] Univ N Carolina, Dept Periodontol, Sch Dent, Chapel Hill, NC 27515 - USA
Total Affiliations: 5
Document type: Journal article
Web of Science Citations: 4

Objective To assess whether single nucleotide polymorphisms (SNPs) in theIL10, IL1A, IL1B, IL4, TNFA, IL6, OPG, RANK,andRANKLgenes, ``classically{''} related with periodontitis, could be associated with susceptibility to T2DM, and also with both diseases concomitantly. Background There are common pathogenic mechanisms in type 2 diabetes mellitus (T2DM) and periodontitis, but the knowledge of the genetic aspect of this is limited. In patients affected by concomitant T2DM and periodontitis, whose incidence is increasing, there is scarce information regarding the gene-phenotype association, including whether there are genes able to influence both diseases as comorbidities. Methods Periodontal clinical parameters and biochemical profile (Insulin, Fasting Glycemia, HbA1c, Triglycerides, Total Cholesterol, HDL-cholesterol, and LDL-cholesterol) data were obtained from 894 individuals divided into following three groups: Healthy (H; n = 347), Periodontitis (P; n = 348), and Periodontitis + T2DM (P + T2DM; n = 199). DNA from oral epithelial cells was collected for genotyping. Associations between SNPs and pathologies were tested by multiple logistic regression models, adjusting for age, sex, and smoking habits. We also investigated whether there are sex or smoking effects of each SNP in these phenotypes. Results The rs1143634-GA (IL1B)SNP showed significantly less likely to develop P + T2DM for all population and mainly for women (adjusted OR = 0.37, 95% CI = 0.16-0.88), while women carrying the rs224320 CT (IL4)were more susceptible to develop P + T2DM (adjusted OR = 1.81, 95% CI = 1.04-3.15). Men carrying the rs1800795-CC (IL6)genotype were less likely to develop T2DM (adjusted OR = 0.12, 95% CI = 0.02-0.70,P = .01). Conclusions Some SNPs in theIL1B,IL4,andIL6genes demonstrated sex-influenced association with concomitant periodontitis and T2DM, increasing the evidence of a common genetic component between these diseases and contributing with the understanding of their common pathogenic mechanisms. (AU)

FAPESP's process: 14/13295-1 - Investigation of the association of genetic variation regarding susceptibility to chronic periodontal disease by OpenArray
Grantee:Rafael Nepomuceno Oliveira
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/18313-3 - Investigation of genetic variations susceptibility to chronic periodontitis by OpenArray®: Biostatistics, Bioinformatics and Functional Analysis
Grantee:Rafael Nepomuceno Oliveira
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 16/03753-8 - Investigation of potential genetic markers of chronic periodontitis associated or not with type 2 diabetes mellitus through patient's genetic susceptibility and both glycemic and lipid profiles
Grantee:Raquel Mantuaneli Scarel Caminaga
Support type: Regular Research Grants
FAPESP's process: 16/08070-6 - Investigation of genetic susceptibility to chronic periodontitis associated with Type 2 Diabetes mellitus
Grantee:Thamiris Cirelli
Support type: Scholarships in Brazil - Doctorate (Direct)