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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Strength Training Modulates Prostate of Wistar Rats Submitted to High-Fat Diet

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Cruz Veras, Allice Santos [1] ; de Freitas, Marcelo Conrado [1] ; Thorpe, Hayley Hope Allyssa [2] ; Seraphim, Patricia Monteiro [3] ; Teixeira, Giovana Rampazzo [1, 4]
Total Authors: 5
[1] Sao Paulo State Univ, Postgrad Program Movement Sci, UNESP, Campus Presidente Prudente, Sao Paulo, SP - Brazil
[2] Univ Guelph, Ontario Vet Coll, Dept Biomed Sci, Guelph, ON - Canada
[3] Univ Estadual Paulista, Dept Physiotherapy, Fac Technol & Sci, Campus Presidente Prudente, Sao Paulo, SP - Brazil
[4] Sao Paulo State Univ, Dept Phys Educ, UNESP, Fac Technol & Sci, Presidente Prudente Campus, BR-19060900 Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Web of Science Citations: 0

Our aim is to evaluate the effects of high-fat diet and strength training on ventral prostate health through investigations of rat prostate histology, endocrine modulation, and the expression of proliferative and apoptotic marker, including androgen receptors (AR), glucocorticoid receptors (GR), B-cell lymphoma 2 (Bcl-2), Bcl-2 associated X protein (BAX), Fas cell surface death receptor (Fas/CD95/Apo-1), and Nuclear Factor Kappa-B (NF-kappa B). Eighty Wistar rats were into one of four subgroups: control (CT), strength training (ST), high-fat diet consumption (HF), and high-fat diet consumption with strength training (HFT). Animals then underwent strength training and/or high-fat diet consumption for 8 or 12 weeks, after which animals were euthanized and markers of prostatic health were evaluated histologically and through immunolabeling. Our results indicate that physical strength training reduced the expression of the prostate cell proliferation marker Bcl-2 while increasing expression of the pro-apoptotic marker BAX, as well as increasing expression of AR and GR relevant in the Bcl-2 pathway. We conclude that a high-fat diet can alter hormone receptor levels and cell-cycle protein expression, thereby modifying prostatic homeostasis, and that strength training was able to reduce prostate damage induced by high-fat diet consumption. (AU)

FAPESP's process: 16/11324-0 - Effects of high fat diet and intermittent resistance physical training in prostate of wistar rats
Grantee:Allice Santos Cruz Veras
Support Opportunities: Scholarships in Brazil - Scientific Initiation