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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Plasma Electrolytic Oxidation as a Feasible Surface Treatment for Biomedical Applications: an in vivo study

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Author(s):
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Braga Polo, Tarik Okon [1] ; da Silva, William Phillip [1] ; Correa Momesso, Gustavo Antonio [1] ; Lima-Neto, Tiburtino Jose [1] ; Barbosa, Stefany [2] ; Cordeiro, Jairo Matozinho [3, 4] ; Hassumi, Jaqueline Suemi [1] ; da Cruz, Nilson Cristino [5] ; Okamoto, Roberta [6] ; Barao, Valentim A. R. [3, 4] ; Faverani, Leonardo P. [1]
Total Authors: 11
Affiliation:
[1] Sao Paulo State Univ Unesp, Sch Dent, Dept Diag & Surg, Rua Jose Bonifacio 1193, BR-16015050 Aracatuba, SP - Brazil
[2] Sao Paulo State Univ Unesp, Sch Dent, Rua Jose Bonifacio 1193, BR-16015050 Aracatuba, SP - Brazil
[3] Univ Campinas UNICAMP, Piracicaba Dent Sch, Dept Prosthodont & Periodontol, Av Limeira 901, BR-13414903 Piracicaba, SP - Brazil
[4] Inst Biomat Tribocorros & Nanomed IBTN, Sao Paulo - Brazil
[5] Sao Paulo State Univ UNESP, Technol Plasma Lab LaPTec, Expt Campus Sorocaba, Sorocaba - Brazil
[6] Sao Paulo State Univ UNESP, Dept Basic Sci, Sch Dent, Rua Jose Bonifacio 1193, BR-16015050 Aracatuba, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 10, n. 1 JUN 19 2020.
Web of Science Citations: 0
Abstract

Objectives: In this in vivo animal study, we evaluated the effect of plasma electrolytic oxidation (PEO) coating on the topographic and biological parameters of implants installed in rats with induced osteoporosis and low-quality bones. Materials and methods: In total 44 Wistar rats (Rattus novergicus), 6 months old, were submitted to ovariectomy (OXV group) and dummy surgery (SHAM group). After 90 days, the ELISA test was performed and the ovariectomy effectiveness was confirmed. In each tibial metaphysis, an implant with PEO coating containing Ca2+ and P5+ molecules were installed, and the other tibia received an implant with SLA acid etching and blasting (AC) (control surface). After 42 days, 16 rats from each group were euthanized, their tibias were removed for histological and immunohistochemical analysis (OPG, RANKL, OC and TRAP), as well as reverse torque biomechanics. Data were submitted to One-way ANOVA or Kruskal-Wallis tests, followed by a Tukey post-test; P<0.05. Histological analyses showed higher bone neoformation values among the members of the PEO group, SHAM and OVX groups. Immunohistochemical analysis demonstrated equilibrium in all groups when comparing surfaces for TRAP, OC and RANKL (P>0.05), whereas OPG showed higher PEO labeling in the OVX group (P<0.05). Biomechanical analysis showed higher reverse torque values (N.cm) for PEO, irrespective of whether they were OVX or SHAM groups (P<0.05). Conclusion: The results indicated that the PEO texturing method favored bone formation and showed higher bone maturation levels during later periods in osteoporotic rats. (AU)

FAPESP's process: 16/20297-6 - The influence of commercially pure Titanium (cpTi) coating with Ca and P incorporation produced by plasma electrolytic oxidation on low density bone: An in vitro, ex-vivo and in vivo study
Grantee:Leonardo Perez Faverani
Support type: Regular Research Grants