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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Arginase and its mechanisms inLeishmaniapersistence

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Pessenda, Gabriela [1] ; da Silva, Joao Santana [1, 2]
Total Authors: 2
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem & Immunol, Ribeirao Preto - Brazil
[2] Fundacao Oswaldo Cruz Bi Inst, Ribeirao Preto - Brazil
Total Affiliations: 2
Document type: Review article
Source: PARASITE IMMUNOLOGY; v. 42, n. 7, SI JUL 2020.
Web of Science Citations: 0

Leishmaniasis is a neglected infectious disease with clinical presentations ranging from asymptomatic or mild symptoms to chronic infection and eventual death. The mechanisms of disease susceptibility and pathology have been extensively studied, but there are no steadfast rules regarding leishmaniasis. A Th1 response is usually associated with infection control, while a predominant Th2 response is detrimental to the patient. In this scenario, the enzymes arginase and inducible nitric oxide synthase represent two possible pathways of immune response. While the former contributes to parasite replication, the latter is crucial for its control. In the present review, we collected study results that associate arginase expression in patients and in experimental models with disease susceptibility/chronicity and show some proposed mechanisms that explain the role of arginase in maintainingLeishmaniainfection, including polyamine and thiol synthesis, tissue-resident macrophage (TRM) proliferation and activation and T-cell suppression and exhaustion. (AU)

FAPESP's process: 17/09746-6 - The role of dermal macrophages in the initial immune response against Leishmania infection
Grantee:Gabriela Pessenda
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 15/25289-9 - Identification and validation of essential genes responsible for the immune response induction in patients with visceral leishmaniasis
Grantee:Gabriela Pessenda
Support Opportunities: Scholarships in Brazil - Doctorate