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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

CandidaBiofilms: An Update on Developmental Mechanisms and Therapeutic Challenges

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de Barros, Patricia Pimentel [1] ; Rossoni, Rodnei Dennis [1] ; de Souza, Cheyenne Marcal [1] ; Scorzoni, Liliana [1] ; Fenley, Juliana De Camargo [1] ; Junqueira, Juliana Campos [1]
Total Authors: 6
[1] Sao Paulo State Univ Unesp, Dept Biosci & Oral Diag, Inst Sci & Technol, Ave Engn Francisco Jose Longo 777, BR-12245000 Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: Mycopathologia; v. 185, n. 3, p. 415-424, JUN 2020.
Web of Science Citations: 0

Fungi of the genusCandidaare important etiological agents of superficial and life-threatening infections in individuals with a compromised immune system. One of the main characteristics ofCandidais its ability to form highly drug tolerance biofilms in the human host. Biofilms are a dynamic community of multiple cell types whose formation over time is orchestrated by a network of transcription regulators. In this brief review, we provide an update of the processes involved in biofilm formation byCandidaspp. (formation, treatment, and control), as well as the transcriptional circuitry that regulates its development and interactions with other microorganisms.Candida albicansis known to build mixed species biofilms with otherCandidaspecies and with various other bacterial species in different host niches. Taken together, these properties play a key role inCandidapathogenesis. In addition, this review gathers recent studies with new insights and perspectives for the treatment and control ofCandidabiofilms. (AU)

FAPESP's process: 19/05664-0 - Exploring the caffeic acid (CA), caffeic acid phenethyl ester (CAPE) and artepillin c (ARTC) as new strategies to eliminate persisters cells of Candida albicans
Grantee:Patrícia Pimentel de Barros
Support type: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 17/19219-3 - Identification of bioactive substances produced by Lactobacillus paracasei 28.4 for the control of oral candidiasis
Grantee:Rodnei Dennis Rossoni
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/02652-6 - Evaluation of the immunomodulatory and antifungal effects of caffeic acid (CA), caffeic acid phenethyl ester (CAPE) and artepillin C (ARC) on C. albicans and development of candidiasis in in vivo model hosts
Grantee:Patrícia Pimentel de Barros
Support type: Scholarships in Brazil - Post-Doctorate