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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Advances in the Design of pH-Sensitive Cubosome Liquid Crystalline Nanocarriers for Drug Delivery Applications

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Mertins, Omar [1, 2] ; Mathews, Patrick D. [2, 3] ; Angelova, Angelina [1, 4]
Total Authors: 3
[1] Univ Paris Saclay, CNRS, UMR8612, Inst Galien Paris Saclay, F-92296 Chatenay Malabry - France
[2] Fed Univ Sao Paulo UNIFESP, Paulista Med Sch, Dept Biophys, Lab Nano Bio Mat LNBM, BR-04023062 Sao Paulo - Brazil
[3] Sorbonne Univ, Museum Natl Hist Nat, CP 26, F-75231 Paris - France
[4] Mathews, Patrick D., Sorbonne Univ, Museum Natl Hist Nat, CP 26, F-75231 Paris, France.Mertins, Omar, Univ Paris Saclay, CNRS, UMR8612, Inst Galien Paris Saclay, F-92296 Chatenay Malabry - France
Total Affiliations: 4
Document type: Review article
Source: NANOMATERIALS; v. 10, n. 5 MAY 2020.
Web of Science Citations: 0

Nanostructure bicontinuous cubic phase self-assembled materials are receiving expanding applications as biocompatible delivery systems in various therapeutic fields. The functionalization of cubosome, spongosome, hexosome and liposome nanocarriers by pH-sensitive lipids and/or pH-sensitive polymer shells offers new opportunities for oral and topical drug delivery towards a new generation of cancer therapies. The electrochemical behavior of drug compounds may favor pH-triggered drug release as well. Here, we highlight recent investigations, which explore the phase behavior of mixed nonlamellar lipid/fatty acid or phospholipid systems for the design of pH-responsive and mucoadhesive drug delivery systems with sustained-release properties. X-ray diffraction and small-angle X-ray scattering (SAXS) techniques are widely used in the development of innovative delivery assemblies through detailed structural analyses of multiple amphiphilic compositions from the lipid/co-lipid/water phase diagrams. pH-responsive nanoscale materials and nanoparticles are required for challenging therapeutic applications such as oral delivery of therapeutic proteins and peptides as well as of poorly water-soluble substances. Perspective nanomedicine developments with smart cubosome nanocarriers may exploit compositions elaborated to overcome the intestinal obstacles, dual-drug loaded pH-sensitive liquid crystalline architectures aiming at enhanced therapeutic efficacy, as well as composite (lipid/polyelectrolyte) types of mucoadhesive controlled release colloidal cubosomal formulations for the improvement of the drugs' bioavailability. (AU)

FAPESP's process: 16/13368-4 - Nanostructured systems: from membrane biomimetic models to carriers of bioactives
Grantee:Karin Do Amaral Riske
Support type: Research Projects - Thematic Grants
FAPESP's process: 19/13147-6 - Studies of the differential expressed immune genes in organs of ornamental fish in response to myxosporeans infection
Grantee:Patrick Mathews Delgado
Support type: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 18/21727-0 - Cubosome drug carriers with bioconjugated functionalities and pH-responsive polymer shells
Grantee:Omar Mertins
Support type: Scholarships abroad - Research