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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Dengue Fever, COVID-19 (SARS-CoV-2), and Antibody-Dependent Enhancement (ADE): A Perspective

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Ulrich, Henning [1] ; Pillat, Micheli M. [2] ; Tarnok, Attila [3, 4, 5]
Total Authors: 3
[1] Univ Sao Paulo, Inst Chem, Dept Biochem, Sao Paulo - Brazil
[2] Univ Fed Santa Maria, Dept Microbiol & Parasitol, Hlth Sci Ctr, Santa Maria, RS - Brazil
[3] Univ Leipzig, Inst Med Informat Stat & Epidemiol IMISE, Leipzig - Germany
[4] Fraunhofer Inst Cell Therapy & Immunol IZI, Dept Therapy Validat, Perlickstr 1, D-04103 Leipzig - Germany
[5] Tsinghua Univ, Dept Precis Instrument, Beijing - Peoples R China
Total Affiliations: 5
Document type: Review article
Source: Cytometry Part A; v. 97, n. 7, SI JUN 2020.
Web of Science Citations: 1

SARS-CoV-2 pandemic and recurrent dengue epidemics in tropical countries have turned into a global health threat. While both virus-caused infections may only reveal light symptoms, they can also cause severe diseases. Here, we review the possible antibody-dependent enhancement (ADE) occurrence, known for dengue infections, when there is a second infection with a different virus strain. Consequently, preexisting antibodies do not neutralize infection, but enhance it, possibly by triggering Fc gamma receptor-mediated virus uptake. No clinical data exist indicating such mechanism for SARS-CoV-2, but previous coronavirus infections or infection of SARS-CoV-2 convalescent with different SARS-CoV-2 strains could promote ADE, as experimentally shown for antibodies against the MERS-CoV or SARS-CoV spike S protein. (c) 2020 International Society for Advancement of Cytometry (AU)

FAPESP's process: 18/08426-0 - Indole alkaloid sub products of Maqui (Aristotelia chilensis) processing as food additives to Alzheimer's Disease treatment
Grantee:Alexander Henning Ulrich
Support Opportunities: Regular Research Grants