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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Gene expression is associated with virulence in murine macrophages infected with Leptospira spp

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Author(s):
de Araujo Junior, Erivelto Correa [1] ; Garcia, Leandro Encarnacao [1] ; Araujo, Matheus Janeck [1] ; Oliveira-Junior, Itamar Souza [2] ; Arnold, Daniel Robert [1] ; Lopes, Flavia Lombardi [1] ; Marinho, Marcia [1]
Total Authors: 7
Affiliation:
[1] Sao Paulo State Univ Unesp, Sch Vet Med, Dept Prod & Anim Hlth, Aracatuba, SP - Brazil
[2] Univ Fed Sao Paulo, Discipline Anesthesia Pain & Intens Med, Dept Surg, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: PLoS One; v. 14, n. 12 DEC 4 2019.
Web of Science Citations: 0
Abstract

Leptospira genus contains species that affect human health with varying degrees of pathogenicity. In this context, we aimed to evaluate the differences in the modulation of host gene expression by strains of Leptospira varying in virulence. Our data showed a high number of differentially expressed transcripts in murine macrophages following 6h of infection. Leptospira infection modulated a set of genes independently of their degree of virulence. However, pathway analysis indicated that Apoptosis, ATM Signaling, and Cell Cycle: G2/M DNA Damage Checkpoint Regulation were exclusively regulated following infection with the virulent strain. Taken together, results demonstrated that species and virulence play a role during host response to Leptospira spp in murine macrophages, which could contribute to understanding the pathogenesis of leptospirosis. (AU)

FAPESP's process: 14/20719-2 - Profile of macrophage activity in vitro against the virulent, attenuated and saprophytic Leptospira spp. sample
Grantee:Márcia Marinho
Support Opportunities: Regular Research Grants