Cascate reactions of progesterone by mycelia and c... - BV FAPESP
Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cascate reactions of progesterone by mycelia and culture broth from marine-derived fungus Aspergillus sydowii CBMAI 935

Full text
Author(s):
Cardoso de Paula, Samuel Filipe [1] ; Meleiro Porto, Andre Luiz [1]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo, Lab Quim Organ & Biocatalise, Inst Quim Sao Carlos, Ave Joao Dagnone 1100, Ed Quim Ambiental, BR-13563120 Sao Carlos, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY; v. 25, MAY 2020.
Web of Science Citations: 0
Abstract

In this work, bio-oxidation cascate reactions of steroid progesterone were performed using culture broth and mycelia from marine-derived fungus Aspergillus sydowii CBMAI 935. The major products obtained from progesterone by Baeyer-Villiger cascate reactions were testosterone and testololactone. The bio-oxydation reactions were performed in quintuplicate experiments (32 degrees C, 130 rpm, pH 7.4); after seven days in presence of culture broth, testosterone and testololactone were isolated in 24% and 36% yield, respectively. The testololactone was also isolated from mycelia after seven days in 87% yield. This study involving the cascate reaction of progesterone demonstrated the microbial biotransformation potential for steroidal drugs in environment by marine-derived fungi. (AU)

FAPESP's process: 16/20155-7 - Biocatalytic reactions of aminolysis and kinetic resolution by lipases and biodegradation of agrochemicals by microorganisms
Grantee:Andre Luiz Meleiro Porto
Support Opportunities: Regular Research Grants