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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Syngonanthus nitens (Bong.) Ruhland Derivatives Loaded into a Lipid Nanoemulsion for Enhanced Antifungal Activity Against Candida parapsilosis

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Author(s):
de Lima, Laura C. [1] ; Ramos, Matheus A. S. [1] ; de Toledo, Luciani G. [1] ; Rodero, Camila F. [2] ; Hilario, Felipe [1] ; dos Santos, Lourdes C. [3] ; Chorilli, Marlus [2] ; Bauab, Tais M. [1]
Total Authors: 8
Affiliation:
[1] Sao Paulo State Univ UNESP, Dept Biol Sci, Sch Pharmaceut Sci, Campus Araraquara, BR-14800903 Araraquara, SP - Brazil
[2] Sao Paulo State Univ UNESP, Dept Drug & Med, Sch Pharmaceut Sci, Campus Araraquara, BR-14800903 Araraquara, SP - Brazil
[3] Sao Paulo State Univ UNESP, Dept Organ Chem, Inst Chem, Campus Araraquara, BR-14800900 Araraquara, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: CURRENT PHARMACEUTICAL DESIGN; v. 26, n. 14, p. 1556-1565, 2020.
Web of Science Citations: 1
Abstract

Background: Vaginal infections caused by non-albicans species have become common in women of all age groups. The resistance of species such as Candida parapsilosis to the various antifungal agents is a risk factor attributed to these types of infections, which instigates the search for new sources of active compounds in vulvovaginal candidiasis (VCC) therapy. Objective: This study evaluated the antifungal activity of Syngonanthus nitens Bong. (Ruhland) derivatives and employed a lipid nanoemulsion as a delivery system. Methods: in this study, a lipid nanoemulsion was employed as a delivery system composed of Cholesterol (10%), soybean phosphatidylcholine: Brij 58 (1: 2) and PBS (pH 7.4) with the addition of 0.5% of a chitosan dispersion (80%), and evaluated the antifungal activity of S. nitens Bong. (Ruhland) derivatives against planktonic cells and biofilms of Candida parapsilosis. By a biomonitoring fractionation, the crude extract (EXT) and one fraction (F2) were selected and incorporated into a lipid nanoemulsion (NL) composed of cholesterol (10%), a 1:2 mixture of soybean phosphatidylcholine:polyoxyethylene -20- cetyl ether (10%), and phosphate buffer solution (pH 7.4) with a 0.5% chitosan dispersion (80%). The NL presented a diameter size between 50-200 nm, pseudoplastic behavior, and positive charge. The EXT and five fractions were active against planktonic cells. Results and Discussion: The incorporation of EXT and F2 into the NL increased antifungal activity and enhanced the anti-biofilm potential. This study classified the use of an NL as an important tool for the administration of S. nitens derivatives in cases of infections caused by this C. parapsisilosis. Conclusion: This work concluded that S. nitens derivatives were important sources of active molecules against C. parapsilosis and the use of a lipid nanoemulsion was an important tool to promote more effective F2 release and to improve the antifungal activity aiming the control of C. parapsilosis infections. (AU)

FAPESP's process: 18/23442-2 - Evaluation of the potential of liposomes for co-encapsulation of amphotericin B and micafungin in the treatment of systemic infection caused by Candida auris
Grantee:Matheus Aparecido dos Santos Ramos
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/18435-4 - Evaluation of the anti-Candida non-albicans potential of fractions of the methanolic extract of Syngonanthus nitens (Bong.) Ruhland incorporated and not incorporated in the nanostructured system
Grantee:Laura Caminitti de Lima
Support type: Scholarships in Brazil - Scientific Initiation