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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Interleukin-6 and the Gut Microbiota Influence Melanoma Progression in Obese Mice

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Pereira, V, Felipe ; Melo, Amanda C. L. [1] ; Silva, Marina B. [1] ; de Melo, Filipe M. [2] ; Terra, Fernanda F. [1] ; Castro, Iris A. [1] ; Perandini, Luiz A. [1] ; Miyagi, Marcelli T. [1] ; Sato, Fabio T. [3] ; Origassa, Clarice S. T. [1] ; Hiyane, I, Meire ; Donat Jr, Jose ; Wasinski, Frederick [4] ; Araujo, Ronaldo C. [4] ; Festuccia, William T. L. [5] ; da Silva, Joao Santana [6] ; Camara, Niels Olsen S. [7]
Total Authors: 17
[1] Pereira, Felipe, V, Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Lab Transplantat Immunobiol, BR-05508900 Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, EPM UNIFESP, Escola Paulista Med, Sao Paulo, SP - Brazil
[3] Univ Estadual Campinas, Inst Biol, UNICAMP, Campinas, SP - Brazil
[4] Univ Fed Sao Paulo, Dept Biophys, Sao Paulo, SP - Brazil
[5] Donat Jr, Jr., Jose, Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, SP - Brazil
[6] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem & Immunol, Ribeirao Preto, SP - Brazil
[7] Hiyane, Meire, I, Pereira, Felipe, V, Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Lab Transplantat Immunobiol, BR-05508900 Sao Paulo, SP - Brazil
Total Affiliations: 7
Document type: Journal article
Web of Science Citations: 0

There is a strong correlation between obesity and cancer. Here, we investigated the influence of IL-6 and gut microbiota of obese mice in melanoma development. We first evaluated B16F10 melanoma growth in preclinical models for obesity: mice deficient for leptin (ob/ob) or adiponectin (AdpKO) and in wild-type mice (WT, C57BL/6J) fed a high-fat diet (HFD; 60% kcal from fat) for 12 weeks. The survival rates of ob/ob and HFD-fed mice were lower than those of their respective controls. AdpKO mice also died earlier than WT control mice. We then verified the involvement of IL-6 signaling in obese mice that were inoculated with melanoma cells. Both ob/ob and AdpKO mice had higher circulating IL-6 levels than wild-type mice. Melanoma tumor volumes in IL-6 KO mice fed an HFD were reduced compared to those of WT mice subjected to the same diet. Also evaluated the effect of microbiota in tumor development. Cohousing and fecal matter transfer experiments revealed that microbiota from ob/ob mice can stimulate tumor development in lean WT mice. Taken together, our data show that in some conditions IL-6 and the gut microbiota are key mediators that link obesity and melanoma. (AU)

FAPESP's process: 13/10318-8 - Immunobiological actions of adipokines in experimental murine model of melanoma.
Grantee:Felipe Valença Pereira
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 17/05264-7 - Cell metabolism, microbiota and immune system: new paradigms in renal diseases physiopathology
Grantee:Niels Olsen Saraiva Câmara
Support Opportunities: Research Projects - Thematic Grants