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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Detection of coinfection with Chikungunya virus and Dengue virus serotype 2 in serum samples of patients in State of Tocantins, Brazil

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Marinho, Robson dos Santos S. [1] ; Sanz Duro, Rodrigo L. [1] ; Santos, Giulia L. [1] ; Hunter, James [1] ; Rodrigues Teles, Maria da Aparecida [2] ; Brustulin, Rafael [3, 4, 2] ; de Padua Milagres, Flavio A. [3, 4, 2, 5] ; Sabino, Ester C. [5, 6] ; Diaz, Ricardo S. [1] ; Komninakis, V, Shirley
Total Authors: 10
[1] V, Univ Fed Sao Paulo, Lab Retrovirol, Sao Paulo 04023062 - Brazil
[2] Lab Cent Saude Publ Tocantins LACEN, Tocantins 77016330 - Brazil
[3] Secretaria Saude Tocantins, Tocantins 77453000 - Brazil
[4] Univ Fed Tocantins, Inst Ciencias Biol, Tocantins 77001090 - Brazil
[5] Univ Sao Paulo, Fac Med, LIM 46, Sao Paulo 01246903 - Brazil
[6] Univ Sao Paulo, Inst Med Trop, Sao Paulo 05403000 - Brazil
Total Affiliations: 6
Document type: Journal article
Source: JOURNAL OF INFECTION AND PUBLIC HEALTH; v. 13, n. 5, p. 724-729, MAY 2020.
Web of Science Citations: 0

Background: The co-circulation of Chikungunya (CHIKV), Dengue (DENV) and Zika (ZIKV) viruses increased the risk of outbreaks and coinfections among them. Here, we report cases of coinfection in clinical samples from state of Tocantins, Brazil. Methods: In 2017, the Central Public Health Laboratory (LACEN) received samples of patients who consulted health units with symptoms compatible with arboviral infections. A total of 102 samples were sent to the Retrovirology Laboratory at the Federal University of Sao Paulo, where they were tested by RT-qPCR to confirm DENV, ZIKV and CHIKV infections and to detect coinfected patients. Results: We identified with CHIKV monoinfection (52), DENV serotypes 1 (28) and serotypes 2 (22). We did not detect ZIKV. Five patients were characterized with coinfection involving CHIKV and DENV serotype 2. Conclusions: The presence of co-circulating arboviruses increases the chance of coinfection and demonstrates the importance of differential diagnosis and vector control. (C) 2020 Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. (AU)

FAPESP's process: 15/19343-0 - Viral metagenomics in individuals with HIV/AIDS late diagnosis
Grantee:Shirley Cavalcante Vasconcelos
Support Opportunities: Regular Research Grants