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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Long-term increase of insulin secretion in mice subjected to pregnancy and lactation

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Author(s):
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Vicente, Julia Modesto [1] ; Santos-Silva, Junia Carolina [1] ; Teixeira, Caio Jordao [1] ; de Souza, Dailson Nogueira [1] ; Vettorazzi, Jean Franciesco [2] ; Furtuoso, Fabiola Sales [1] ; Adabo, Isabel Gouveia [1] ; Sato, Fabio Takeo [3] ; Ramirez Vinolo, Marco Aurelio [3] ; Carneiro, Everardo Magalhaes [2] ; Bordin, Silvana [4] ; Anhe, Gabriel Forato [1]
Total Authors: 12
Affiliation:
[1] Univ Estadual Campinas, Fac Med Sci, Dept Pharmacol, Campinas - Brazil
[2] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, Campinas - Brazil
[3] Univ Estadual Campinas, Inst Biol, Dept Genet Evolut Microbiol & Immunol, Campinas - Brazil
[4] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: ENDOCRINE CONNECTIONS; v. 9, n. 4, p. 299-308, APR 2020.
Web of Science Citations: 0
Abstract

Purpose: Observational studies show that longer breastfeeding periods reduce maternal risk of type 2 diabetes mellitus. However, it is currently unknown if the long-term benefits of breastfeeding for maternal glucose homeostasis are linked to changes in the endocrine pancreas. Methods: We presently evaluated functional, morphological and molecular aspects of the endocrine pancreas of mice subjected to two sequential cycles of pregnancy and lactation (L21). Age-matched mice not allowed to breastfeed (LO) and virgin mice were used as controls. Results: L21 mice exhibited increased tolerance and increased glucose-stimulated insulin secretion (GSIS) by isolated islets. Pancreatic islets of L21 mice did not present evident morphological changes to justify the increased GSIS. On the other hand, islets of L21 mice exhibited a reduction in Cavb3 and Kir6.2 expression with concordant increased intracellular Ca2+ levels after challenge with glucose. Conclusion: Altogether, the present findings show the breastfeeding exerts long-term benefits for maternal endocrine pancreas by increasing intracellular Ca2+ levels and GSIS. (AU)

FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
Grantee:Licio Augusto Velloso
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 15/12680-1 - Lon-term impacts of breastfeeding on maternal metabolism: Participation of microRNAs
Grantee:Gabriel Forato Anhê
Support type: Regular Research Grants
FAPESP's process: 17/11138-4 - Effect of pregnancy followed by lactation on miRNAs modulation of maternal pancreatic islets
Grantee:Julia Modesto Vicente
Support type: Scholarships in Brazil - Scientific Initiation