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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Sepsis-induced encephalopathy impairs descending nociceptive pathways in rats

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Cazuza, Rafael Alves [1] ; Santos-Junior, Nilton Nascimento [2] ; Angenendt Costa, Luis Henrique [3, 2] ; Rocha Catalao, Carlos Henrique [3, 2] ; Mendes-Gomes, Joyce [1, 4] ; Alves da Rocha, Maria Jose [2] ; Andrade Leite-Panissi, Christie Ramos [1]
Total Authors: 7
[1] Univ Sao Paulo, Sch Philosophy Sci & Literature Ribeirao Preto, Dept Psychol, BR-14040901 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Dent Fac, Dept Basic & Oral Biol, BR-14040904 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav Sci, BR-14049900 Ribeirao Preto, SP - Brazil
[4] UNIFADRA FUNDEC Med Sch, BR-17900000 Dracena, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Journal of Neuroimmunology; v. 342, MAY 15 2020.
Web of Science Citations: 0

Sepsis-associated encephalopathy (SAE) is a significant problem in patients with sepsis, and it is associated with a decrease in cognitive and sensitivity capability induced by systemic inflammation. SAE is implicated in reversible brain damage of several regions related to cognition, emotion, and sensation; however, it is not well established if it could affect brain regions associated with nociceptive modulation. Here were evaluated the nociceptive thresholds in rats with systemic inflammation induced by cecal ligation puncture (CLP). After 24 h of CLP, it was observed an increase in nociceptive threshold in all tests. Periaqueductal gray, rostroventral medulla, critical regions for descending nociceptive modulation, were evaluated and showed enhanced pro-inflammatory cytokines as well as glial activation. These results suggest that systemic inflammation could compromise descending facilitatory pathways, impairing nociceptive sensory functioning. (AU)

FAPESP's process: 17/11213-6 - Involvement of carbon monoxide in modulation of emotional behavior in endotoxemic rats.
Grantee:Christie Ramos Andrade Leite Panissi
Support Opportunities: Regular Research Grants