Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Photobiomodulation Therapy is Able to Modulate PGE(2) Levels in Patients With Chronic Non-Specific Low Back Pain: A Randomized Placebo-Controlled Trial

Full text
Tomazoni, Shaiane S. [1, 2, 3] ; Costa, Leonardo O. P. [1] ; Joensen, Jon [2] ; Stausholm, Martin B. [2] ; Naterstad, Ingvill F. [2] ; Ernberg, Malin [4, 5] ; Leal-Junior, Ernesto Cesar P. [2, 3, 6, 7] ; Bjordal, Jan M. [2]
Total Authors: 8
[1] Univ Cidade Sao Paulo, Cesario Galeno, Masters & Doctoral Programs Phys Therapy, BR-03071000 Cesario Galeno, SP - Brazil
[2] Physiotherapy Res Grp, Dept Global Publ Hlth & Primary Care, N-5018 Bergen - Norway
[3] ELJ Consultancy, Sci Consultants, Ave Chibaras, BR-04076000 Sao Paulo - Brazil
[4] Karolinska Inst, Dept Dent Med, SE-14104 Huddinge - Sweden
[5] SCON, SE-14104 Huddinge - Sweden
[6] Nove de Julho Univ, Lab Phototherapy & Innovat Technol Hlth, BR-01525000 Vergueiro, SP - Brazil
[7] Nove de Julho Univ, Postgrad Program Rehabil Sci, BR-01525000 Vergueiro, SP - Brazil
Total Affiliations: 7
Document type: Journal article
Source: Lasers in Surgery and Medicine; v. 53, n. 2 APR 2020.
Web of Science Citations: 1

Background and Objectives Non-specific low back pain (LBP) is responsible for triggering increased biomarkers levels. In this way, photobiomodulation therapy (PBMT) may be an interesting alternative to treat these patients. One of the possible biological mechanisms of PBMT involved to decrease pain intensity in patients with musculoskeletal disorders is modulation of the inflammatory mediators' levels. The aim of this study was to evaluate the effects of PBMT compared with placebo on inflammatory mediators' levels and pain intensity in patients with chronic non-specific LBP. Study Design/Materials and Methods A prospectively registered, randomized triple-blinded (volunteers, therapists, and assessors), placebo-controlled trial was performed. Eighteen patients with chronic non-specific LBP were recruited and treated with a single session of active PBMT or placebo PBMT. The primary outcome of the study was serum prostaglandin E-2 levels and the secondary outcomes were tumor necrosis factor-alpha, interleukin-6 levels, and pain intensity. All outcomes were measured before and after 15 minutes of treatment session. Results PBMT was able to decrease prostaglandin E-2 levels at post-treatment compared with placebo, with a mean difference of -1470 pg/ml, 95% confidence interval -2906 to -33.67 in patients with LBP. There was no difference between groups in the other measured outcomes. Patients did not report any adverse events. Conclusion Our results suggest that PBMT was able to modulate prostaglandin E-2 levels, indicating that this may be one of the mechanisms involved in the analgesic effects of PBMT in patients with LBP. Trial registration number (): NCT03859505. Lasers Surg. Med. (c) 2020 The Authors. Lasers in Surgery and Medicine published by Wiley Periodicals, Inc. (AU)

FAPESP's process: 17/18863-6 - Effects of photobiomodulation therapy on inflammatory mediators in patients with chronic non-specific low back pain: a randomized placebo-controlled trial
Grantee:Shaiane da Silva Tomazoni
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor