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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Assembly and antifungal effect of a new fluconazole-carrier nanosystem

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de Lima, Taynara M. T. [1] ; Arias, Lais S. [2] ; Afanaci, Leticia F. [3] ; Ferraresse, Raphael F. B. [3] ; Neto, Francisco N. [2] ; de Lima, Bruno H. R. ; Straioto, Fabiana G. [1] ; de Camargo, Emerson R. [4] ; Pessan, Juliano P. [2] ; Monteiro, Douglas R. [1]
Total Authors: 10
[1] Univ Western Sao Paulo UNOESTE, Grad Program Dent GPD Masters Degree, BR-19050920 Presidente Prudente Sao - Brazil
[2] Sao Paulo State Univ Unesp, Sch Dent, Dept Prevent & Restorat Dent, BR-16015050 Aracatuba Sao Paulo - Brazil
[3] Univ Western Sao Paulo UNOESTE, Sch Dent, BR-19050920 Presidente Prudente Sao - Brazil
[4] Fed Univ Sao Carlos UFSCar, Dept Chem, BR-13565905 Sao Carlos, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: FUTURE MICROBIOLOGY; v. 15, n. 4, p. 273-286, MAR 2020.
Web of Science Citations: 5

Aim: To assemble, characterize and assess the antifungal effects of a new fluconazole (FLZ)-carrier nanosystem. Materials \& methods: The nanosystem was prepared by loading FLZ on chitosan (CS)-coated iron oxide nanoparticles (IONPs). Antifungal effects were evaluated on planktonic cells (by minimum inhibitory concentration determination) and on biofilms (by quantification of cultivable cells, total biomass, metabolism and extracellular matrix) of Candida albicans and Candida glabrata. Results: Characterization results ratified the formation of a nanosystem (<320 nm) with FLZ successfully embedded. IONPs-CS-FLZ nanosystem reduced minimum inhibitory concentration values and, in general, showed similar antibiofilm effects compared with FLZ alone. Conclusion: IONPs-CS-FLZ nanosystem was more effective than FLZ mainly in inhibiting Candida planktonic cells. This nanocarrier has potential to fight fungal infections. (AU)

FAPESP's process: 17/24416-2 - Synthesis and antibiofilm effect of two new carrier nanosystems of antifungal drugs
Grantee:Douglas Roberto Monteiro
Support Opportunities: Regular Research Grants
FAPESP's process: 17/08976-8 - Antifungal effect of a fluconazole carrier nanosystem on Candida albicans and Candida glabrata
Grantee:Letícia Facholi Afanaci
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 17/08980-5 - Effect of a fluconazole carrier nanosystem on the extracellular matrix composition and structure of Candida biofilms
Grantee:Raphael Fernando Barion Ferraresse
Support Opportunities: Scholarships in Brazil - Scientific Initiation