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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Defensive behaviors and brain regional activation changes in rats confronting a snake

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Mendes-Gomes, Joyce [1, 2, 3] ; Motta, Simone Cristina [4] ; Bindi, Ricardo Passoni [4] ; de Oliveira, Amanda Ribeiro [4] ; Ullah, Farhad [5] ; Baldo, Marcus Vinicius C. [6] ; Coimbra, Norberto Cysne [1, 2, 3] ; Canteras, Newton Sabino [4] ; Blanchard, D. Caroline [7, 4]
Total Authors: 9
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo FMRP USP, Ribeirao Preto Sch Med, Ophidiarium LNN FMRP USP INeC, BR-14049900 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo FMRP USP, NAP USP Neurobiol Emot Res Ctr NuPNE, Ribeirao Preto Med Sch, BR-14049900 Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Av Lineu Presses 2415, BR-05508000 Sao Paulo, SP - Brazil
[5] Islamia Coll Univ, Dept Zool, Grand Trunk Rd, Peshawar 25120 - Pakistan
[6] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508000 Sao Paulo, SP - Brazil
[7] Univ Hawaii Manoa, Pacific Biosci Res Ctr, Honolulu, HI 96822 - USA
Total Affiliations: 7
Document type: Journal article
Source: Behavioural Brain Research; v. 381, MAR 2 2020.
Web of Science Citations: 0

In the present study, we examined behavioral and brain regional activation changes of rats). To a non-mammalian predator, a wild rattler snake (Crotalus durissus terrificus). Accordingly, during snake threat, rat subjects showed a striking and highly significant behavioral response of freezing, stretch attend, and, especially, spatial avoidance of this threat. The brain regional activation patterns for these rats were in broad outline similar to those of rats encountering other predator threats, showing Fos activation of sites in the amygdala, hypothalamus, and periaqueductal gray matter. In the amygdala, only the lateral nucleus showed significant activation, although the medial nucleus, highly responsive to olfaction, also showed higher activation. Importantly, the hypothalamus, in particular, was somewhat different, with significant Fos increases in the anterior and central parts of the ventromedial hypothalamic nucleus (VMH), in contrast to patterns of enhanced Fos expression in the dorsomedial VMH to cat predators, and in the ventrolateral VMH to an attacking conspecific. In addition, the juxtodorsalmedial region of the lateral hypothalamus showed enhanced Fos activation, where inputs from the septo-hippocampal system may suggest the potential involvement of hippocampal boundary cells in the very strong spatial avoidance of the snake and the area it occupied. Notably, these two hypothalamic paths appear to merge into the dorsomedial part of the dorsal premammillary nucleus and dorsomedial and lateral parts of the periaqueductal gray, all of which present significant increases in Fos expression and are likely to be critical for the expression of defensive behaviors in responses to the snake threat. (AU)

FAPESP's process: 17/11855-8 - Study of corpus striatum and ventral mesencephalon endocanabinoid influence on neostriato-nigro-tectal GABAergic pathways during panic reactions of rodents threatened by venomous snakes
Grantee:Norberto Cysne Coimbra
Support Opportunities: Regular Research Grants
FAPESP's process: 14/05432-9 - Neural bases of fear and aggression
Grantee:Newton Sabino Canteras
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 13/13398-2 - Investigation of chronic neuropathic pain and post-traumatic stress disorder comorbidity: role of glutamatergic, cannabinoid and vanilloid systems involving the prelimbic cortex and the periaqueductal grey
Grantee:Joyce Mendes Gomes Tessari
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 18/00576-3 - Investigation of the neuronal activity in the different functional columns of periaqueductal gray matter in response to a predatory threat and a predatory context
Grantee:Ricardo Passoni Bindi
Support Opportunities: Scholarships in Brazil - Doctorate