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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Association between trace elements in serum from bipolar disorder and schizophrenia patients considering treatment effects

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Santa Cruz, Elisa C. [1] ; Madrid, Katherine C. [2] ; Arruda, Marco A. Z. [3, 2] ; Sussulini, Alessandra [1, 3]
Total Authors: 4
[1] Univ Campinas UNICAMP, Inst Chem, Dept Analyt Chem, Lab Bioanalyt & Integrated Omics LaBIOm, POB 6154, BR-13083970 Campinas, SP - Brazil
[2] Univ Campinas UNICAMP, Inst Chem, Dept Analyt Chem, Spectrometry Sample Preparat & Mech Grp GEPAM, POB 6154, BR-13083970 Campinas, SP - Brazil
[3] Univ Campinas UNICAMP, Inst Chem, Natl Inst Sci & Technol Bioanalyt INCTBio, POB 6154, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Web of Science Citations: 0

Background: Imbalances in metal concentrations have been suggested to contribute to the pathophysiology of different brain disorders, such as bipolar disorder (BD) and schizophrenia (SCZ). Objectives: The aim of this exploratory study is to evaluate the association between the concentrations of macro/trace elements in serum from BD and SCZ patients considering the effects from different treatments. Methods: Eleven subjects with SCZ, seven with BD treated with lithium (BDL) and eight subjects with BD treated with other medications except lithium (BDN) were recruited for the study, as well as eleven healthy controls (HC). Serum concentrations of eleven macro/trace elements (Se, Zn, Fe, K, Ca, Mg, P, Al, Cu, Mn, and Ni) were determined using inductively coupled plasma mass spectrometry (ICP-MS). Results: Se and Zn concentrations were significantly lower for patients with SCZ and BD in comparison to HC by one-way ANOVA test. Moreover, serum concentrations for Fe were significantly higher (p < 0.05) in BDN (548 +/- 92 mu g L-1) and SCZ (632 +/- 279 mu g L-1) in comparison to HC (421 +/- 121 mu g L-1). A significant negative correlation was reported between Se and Fe in BDL group (r = -0.935, p < 0.05). In addition, a significantly higher Cu/Zn ratio was determined in SCZ group against HC (ratio = 2.4, p = 0.028). Conclusions: The obtained results suggest that the imbalance in Fe concentrations is an effect of BD treatment. Lithium is supposed to have an antagonist effect for Se in BDL patients. A negative correlation reported between Fe and BMI in SCZ group could be related to antipsychotic treatment and the Cu/Zn ratio reported could be considered as a suggesting parameter to relate oxidative stress to SCZ. Future studies including larger number of patients with SCZ and BD before and after treatment are necessary to confirm the investigative results presented herein. (AU)

FAPESP's process: 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis
Grantee:Lauro Tatsuo Kubota
Support type: Research Projects - Thematic Grants
FAPESP's process: 18/01525-3 - Metabolomic studies of depression patients treated with ayahuasca
Grantee:Alessandra Sussulini
Support type: Regular Research Grants